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The primary immune response in patients with selective IgA deficiency.
Clin Exp Immunol 1983; 54(3):778-84CE

Abstract

The primary immune response in vivo of 20 patients with selective IgA deficiency was studied and compared to controls. The primary cellular immune response tested by dinitrochlorobenzene (DNCB) was decreased in many patients. The primary humoral immune response was elicited by immunization with the test immunogen Helix pomatia haemocyanin (HPH). Using a direct ELISA technique antibodies against HPH of the IgA, IgG and IgM class were measured. Two weeks after immunization no response of IgA anti-HPH was seen except in three patients who showed a low but detectable antibody level. In spite of normal or even elevated serum IgG and IgM levels there was a significantly lower response of the IgG and IgM anti-HPH antibodies at 2 weeks after immunization as compared to the controls followed by a further decline at 6 weeks. We conclude that selective IgA deficiency is often accompanied by more general disturbances in humoral and cellular immunity to newly encountered antigens.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6652975

Citation

De Graeff, P A., et al. "The Primary Immune Response in Patients With Selective IgA Deficiency." Clinical and Experimental Immunology, vol. 54, no. 3, 1983, pp. 778-84.
De Graeff PA, The TH, van Munster PJ, et al. The primary immune response in patients with selective IgA deficiency. Clin Exp Immunol. 1983;54(3):778-84.
De Graeff, P. A., The, T. H., van Munster, P. J., Out, T. A., Vossen, J. M., & Zegers, B. J. (1983). The primary immune response in patients with selective IgA deficiency. Clinical and Experimental Immunology, 54(3), pp. 778-84.
De Graeff PA, et al. The Primary Immune Response in Patients With Selective IgA Deficiency. Clin Exp Immunol. 1983;54(3):778-84. PubMed PMID: 6652975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The primary immune response in patients with selective IgA deficiency. AU - De Graeff,P A, AU - The,T H, AU - van Munster,P J, AU - Out,T A, AU - Vossen,J M, AU - Zegers,B J, PY - 1983/12/1/pubmed PY - 1983/12/1/medline PY - 1983/12/1/entrez SP - 778 EP - 84 JF - Clinical and experimental immunology JO - Clin. Exp. Immunol. VL - 54 IS - 3 N2 - The primary immune response in vivo of 20 patients with selective IgA deficiency was studied and compared to controls. The primary cellular immune response tested by dinitrochlorobenzene (DNCB) was decreased in many patients. The primary humoral immune response was elicited by immunization with the test immunogen Helix pomatia haemocyanin (HPH). Using a direct ELISA technique antibodies against HPH of the IgA, IgG and IgM class were measured. Two weeks after immunization no response of IgA anti-HPH was seen except in three patients who showed a low but detectable antibody level. In spite of normal or even elevated serum IgG and IgM levels there was a significantly lower response of the IgG and IgM anti-HPH antibodies at 2 weeks after immunization as compared to the controls followed by a further decline at 6 weeks. We conclude that selective IgA deficiency is often accompanied by more general disturbances in humoral and cellular immunity to newly encountered antigens. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/6652975/The_primary_immune_response_in_patients_with_selective_IgA_deficiency_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/6652975/ DB - PRIME DP - Unbound Medicine ER -