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Indapamide: a unique diuretic?
Drug Intell Clin Pharm. 1983 Dec; 17(12):898-9.DI

Abstract

Indapamide (Lozol) is a new diuretic and antihypertensive agent. The drug appears to have a unique mechanism of action, combining diuretic effects with a direct vascular action, presumably secondary to calcium channel blockade. Available studies indicate that indapamide is comparable to hydrochlorothiazide, chlorothiazide, furosemide, and other diuretic agents in the management of hypertension and edema. The drug produces toxicity similar to that of the thiazide and loop diuretics; however, it does not appear to increase cholesterol levels. Although it is claimed that indapamide produces no effect on glucose levels, hyperglycemia has been reported. Indapamide is safe and effective for treatment of hypertension in mild to severe renal impairment, but advantages over furosemide are questionable. Indapamide is a unique diuretic, but does not appear to offer advantages over other available agents.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6653405

Citation

Conner, C S.. "Indapamide: a Unique Diuretic?" Drug Intelligence & Clinical Pharmacy, vol. 17, no. 12, 1983, pp. 898-9.
Conner CS. Indapamide: a unique diuretic? Drug Intell Clin Pharm. 1983;17(12):898-9.
Conner, C. S. (1983). Indapamide: a unique diuretic? Drug Intelligence & Clinical Pharmacy, 17(12), 898-9.
Conner CS. Indapamide: a Unique Diuretic. Drug Intell Clin Pharm. 1983;17(12):898-9. PubMed PMID: 6653405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indapamide: a unique diuretic? A1 - Conner,C S, PY - 1983/12/1/pubmed PY - 1983/12/1/medline PY - 1983/12/1/entrez SP - 898 EP - 9 JF - Drug intelligence & clinical pharmacy JO - Drug Intell Clin Pharm VL - 17 IS - 12 N2 - Indapamide (Lozol) is a new diuretic and antihypertensive agent. The drug appears to have a unique mechanism of action, combining diuretic effects with a direct vascular action, presumably secondary to calcium channel blockade. Available studies indicate that indapamide is comparable to hydrochlorothiazide, chlorothiazide, furosemide, and other diuretic agents in the management of hypertension and edema. The drug produces toxicity similar to that of the thiazide and loop diuretics; however, it does not appear to increase cholesterol levels. Although it is claimed that indapamide produces no effect on glucose levels, hyperglycemia has been reported. Indapamide is safe and effective for treatment of hypertension in mild to severe renal impairment, but advantages over furosemide are questionable. Indapamide is a unique diuretic, but does not appear to offer advantages over other available agents. SN - 0012-6578 UR - https://www.unboundmedicine.com/medline/citation/6653405/Indapamide:_a_unique_diuretic DB - PRIME DP - Unbound Medicine ER -
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