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Evaluation of tolerance in long-term treatment of cancer pain with epidural morphine.
Int J Clin Pharmacol Ther Toxicol. 1983 Nov; 21(11):587-90.IJ

Abstract

The effect of epidural morphine as a pain reliever was evaluated. A catheter was placed in the epidural space in 43 patients suffering from cancer pain related to dermatomeres of the thorax and lumbosacral region for an average period of 38 days (range 3-257 days). The daily dose of morphine hydrochloride varied from 1 to 5 mg with an average dose of 4.23 (+/- 2.4) mg. The treatment was divided into 10-day periods and for each of these periods the average daily dose relative to the total number of cases was calculated. The results showed no significant increase of the dose of epidural morphine in the first 10 decade periods. The authors concluded that pain relief treatment with equal doses maintains its effect for quite a long period of time in patients with often limited life expectancy.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6654534

Citation

Caputi, C A., et al. "Evaluation of Tolerance in Long-term Treatment of Cancer Pain With Epidural Morphine." International Journal of Clinical Pharmacology, Therapy, and Toxicology, vol. 21, no. 11, 1983, pp. 587-90.
Caputi CA, Busca G, Fogliardi F, et al. Evaluation of tolerance in long-term treatment of cancer pain with epidural morphine. Int J Clin Pharmacol Ther Toxicol. 1983;21(11):587-90.
Caputi, C. A., Busca, G., Fogliardi, F., & Giugliano, F. (1983). Evaluation of tolerance in long-term treatment of cancer pain with epidural morphine. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 21(11), 587-90.
Caputi CA, et al. Evaluation of Tolerance in Long-term Treatment of Cancer Pain With Epidural Morphine. Int J Clin Pharmacol Ther Toxicol. 1983;21(11):587-90. PubMed PMID: 6654534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of tolerance in long-term treatment of cancer pain with epidural morphine. AU - Caputi,C A, AU - Busca,G, AU - Fogliardi,F, AU - Giugliano,F, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 587 EP - 90 JF - International journal of clinical pharmacology, therapy, and toxicology JO - Int J Clin Pharmacol Ther Toxicol VL - 21 IS - 11 N2 - The effect of epidural morphine as a pain reliever was evaluated. A catheter was placed in the epidural space in 43 patients suffering from cancer pain related to dermatomeres of the thorax and lumbosacral region for an average period of 38 days (range 3-257 days). The daily dose of morphine hydrochloride varied from 1 to 5 mg with an average dose of 4.23 (+/- 2.4) mg. The treatment was divided into 10-day periods and for each of these periods the average daily dose relative to the total number of cases was calculated. The results showed no significant increase of the dose of epidural morphine in the first 10 decade periods. The authors concluded that pain relief treatment with equal doses maintains its effect for quite a long period of time in patients with often limited life expectancy. SN - 0174-4879 UR - https://www.unboundmedicine.com/medline/citation/6654534/Evaluation_of_tolerance_in_long_term_treatment_of_cancer_pain_with_epidural_morphine_ DB - PRIME DP - Unbound Medicine ER -