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Comparative effects of some autonomic drugs on lizard (Agama agama) and tortoise (Kinixys crosa) isolated rectum.
Methods Find Exp Clin Pharmacol. 1983 Nov; 5(9):631-4.MF

Abstract

The effects of some cholinomimetic and sympathomimetic drugs have been investigated on the isolated rectal muscles of West African rainbow lizard (Agama agama) and land tortoise (Kinixys crosa). Acetylcholine and its natural or synthetic analogues evoked concentration-related atropine-sensitive contractions of the muscle preparations, whereas all the catecholamines examined relaxed the lizard (and guinea-pig), but not the tortoise, isolated rectum in a dose-dependent fashion. The ganglionic stimulant drugs used, nicotine and DMPP, did not produce any effect on the isolated rectum of the two reptiles, although they contracted the guinea-pig isolated rectum in a concentration-dependent manner. Concentrations of physostigmine, which induced spasms or contractions in the isolated rectum of the guinea-pig, failed to excite reptilian rectal muscle preparations. Histamine induced biphasic responses in the lizard isolated rectum without affecting the isolated rectum of the tortoise. Serotonin (5-HT) which contracted the isolated rectum of the guinea-pig (like histamine) also provoked variable contractions of the lizard rectum but did not affect the tortoise isolated rectum. It is therefore concluded that although the rectal smooth muscles of these two terrestrial West African reptiles possess cholinergic innervation with mainly "muscarinic" cholinoceptors, their autonomic innervation differs from that of a conventional mammalian (e.g. guinea-pig) gastrointestinal tract smooth muscle.

Authors

No affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6668973

Citation

Makanju, O O.. "Comparative Effects of some Autonomic Drugs On Lizard (Agama Agama) and Tortoise (Kinixys Crosa) Isolated Rectum." Methods and Findings in Experimental and Clinical Pharmacology, vol. 5, no. 9, 1983, pp. 631-4.
Makanju OO. Comparative effects of some autonomic drugs on lizard (Agama agama) and tortoise (Kinixys crosa) isolated rectum. Methods Find Exp Clin Pharmacol. 1983;5(9):631-4.
Makanju, O. O. (1983). Comparative effects of some autonomic drugs on lizard (Agama agama) and tortoise (Kinixys crosa) isolated rectum. Methods and Findings in Experimental and Clinical Pharmacology, 5(9), 631-4.
Makanju OO. Comparative Effects of some Autonomic Drugs On Lizard (Agama Agama) and Tortoise (Kinixys Crosa) Isolated Rectum. Methods Find Exp Clin Pharmacol. 1983;5(9):631-4. PubMed PMID: 6668973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative effects of some autonomic drugs on lizard (Agama agama) and tortoise (Kinixys crosa) isolated rectum. A1 - Makanju,O O, PY - 1983/11/1/pubmed PY - 1983/11/1/medline PY - 1983/11/1/entrez SP - 631 EP - 4 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 5 IS - 9 N2 - The effects of some cholinomimetic and sympathomimetic drugs have been investigated on the isolated rectal muscles of West African rainbow lizard (Agama agama) and land tortoise (Kinixys crosa). Acetylcholine and its natural or synthetic analogues evoked concentration-related atropine-sensitive contractions of the muscle preparations, whereas all the catecholamines examined relaxed the lizard (and guinea-pig), but not the tortoise, isolated rectum in a dose-dependent fashion. The ganglionic stimulant drugs used, nicotine and DMPP, did not produce any effect on the isolated rectum of the two reptiles, although they contracted the guinea-pig isolated rectum in a concentration-dependent manner. Concentrations of physostigmine, which induced spasms or contractions in the isolated rectum of the guinea-pig, failed to excite reptilian rectal muscle preparations. Histamine induced biphasic responses in the lizard isolated rectum without affecting the isolated rectum of the tortoise. Serotonin (5-HT) which contracted the isolated rectum of the guinea-pig (like histamine) also provoked variable contractions of the lizard rectum but did not affect the tortoise isolated rectum. It is therefore concluded that although the rectal smooth muscles of these two terrestrial West African reptiles possess cholinergic innervation with mainly "muscarinic" cholinoceptors, their autonomic innervation differs from that of a conventional mammalian (e.g. guinea-pig) gastrointestinal tract smooth muscle. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/6668973/Comparative_effects_of_some_autonomic_drugs_on_lizard__Agama_agama__and_tortoise__Kinixys_crosa__isolated_rectum_ DB - PRIME DP - Unbound Medicine ER -