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Evaluation of gliadin antibodies for detection of coeliac disease.
Scand J Gastroenterol. 1983 May; 18(3):377-83.SJ

Abstract

To evaluate assay of gliadin antibodies of different immunoglobulin classes as a test for detection of coeliac disease, we analysed sera from 36 adult patients and 8 children with coeliac disease, 62 patients with other gastrointestinal diseases, and 124 blood donors with diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA). Depending on the choice of reference levels for gliadin antibodies of the IgA and IgG classes, respectively, we found a diagnostic sensitivity for coeliac disease of 93-86% and a diagnostic specificity of 95-100%. Determination of gliadin antibodies by DIG-ELISA can thus be used as a test for detection of coeliac disease and selection of patients for small-intestinal biopsy.

Authors

Kilander AF
No affiliation info available
Dotevall G
No affiliation info available
Fällström SP
No affiliation info available
Gillberg RE
No affiliation info available
Nilsson LA
No affiliation info available
Tarkowski A
No affiliation info available

MeSH

AdolescentAdultAgedAntibodiesBlood DonorsCeliac DiseaseChildChild, PreschoolColitis, UlcerativeColonic Diseases, FunctionalCrohn DiseaseEnzyme-Linked Immunosorbent AssayEvaluation Studies as TopicFemaleGliadinHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MInfantMaleMiddle AgedPlant Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6673063

Citation

Kilander, A F., et al. "Evaluation of Gliadin Antibodies for Detection of Coeliac Disease." Scandinavian Journal of Gastroenterology, vol. 18, no. 3, 1983, pp. 377-83.
Kilander AF, Dotevall G, Fällström SP, et al. Evaluation of gliadin antibodies for detection of coeliac disease. Scand J Gastroenterol. 1983;18(3):377-83.
Kilander, A. F., Dotevall, G., Fällström, S. P., Gillberg, R. E., Nilsson, L. A., & Tarkowski, A. (1983). Evaluation of gliadin antibodies for detection of coeliac disease. Scandinavian Journal of Gastroenterology, 18(3), 377-83.
Kilander AF, et al. Evaluation of Gliadin Antibodies for Detection of Coeliac Disease. Scand J Gastroenterol. 1983;18(3):377-83. PubMed PMID: 6673063.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of gliadin antibodies for detection of coeliac disease. AU - Kilander,A F, AU - Dotevall,G, AU - Fällström,S P, AU - Gillberg,R E, AU - Nilsson,L A, AU - Tarkowski,A, PY - 1983/5/1/pubmed PY - 1983/5/1/medline PY - 1983/5/1/entrez SP - 377 EP - 83 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 18 IS - 3 N2 - To evaluate assay of gliadin antibodies of different immunoglobulin classes as a test for detection of coeliac disease, we analysed sera from 36 adult patients and 8 children with coeliac disease, 62 patients with other gastrointestinal diseases, and 124 blood donors with diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA). Depending on the choice of reference levels for gliadin antibodies of the IgA and IgG classes, respectively, we found a diagnostic sensitivity for coeliac disease of 93-86% and a diagnostic specificity of 95-100%. Determination of gliadin antibodies by DIG-ELISA can thus be used as a test for detection of coeliac disease and selection of patients for small-intestinal biopsy. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/6673063/Evaluation_of_gliadin_antibodies_for_detection_of_coeliac_disease_ L2 - https://medlineplus.gov/celiacdisease.html DB - PRIME DP - Unbound Medicine ER -