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Not the artificial beta cell algorithms but their parameter values are important in automated glucose control of insulin-dependent diabetes.

Abstract

The blood glucose responses of diabetic dogs on the ABC are nearly identical if different algorithms, but equivalent sets of parameters are used to control the glucose-dependent insulin infusion. There are however some differences in the insulin doses applied, which obviously result from different response kinetics of the particular formula to the minor BG oscillations that always occur. In the practical application of closed-loop systems the control constants should be individually estimated on the basis of certain controlled plant characteristics. For use in patients the checking and modeling systems still have to be simplified. The limits of the study, i.e. the fact that normoglycemia was restored for a short time only using the IV instead of the physiological portal route, remain the subject of further investigation.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6673274

Citation

Fischer, U, et al. "Not the Artificial Beta Cell Algorithms but Their Parameter Values Are Important in Automated Glucose Control of Insulin-dependent Diabetes." Transactions - American Society for Artificial Internal Organs, vol. 29, 1983, pp. 488-91.
Fischer U, Jutzi E, Albrecht G, et al. Not the artificial beta cell algorithms but their parameter values are important in automated glucose control of insulin-dependent diabetes. Trans Am Soc Artif Intern Organs. 1983;29:488-91.
Fischer, U., Jutzi, E., Albrecht, G., Abel, P., Salzsieder, E., Freyse, E. J., Detscheff, W., & Lemke, K. (1983). Not the artificial beta cell algorithms but their parameter values are important in automated glucose control of insulin-dependent diabetes. Transactions - American Society for Artificial Internal Organs, 29, 488-91.
Fischer U, et al. Not the Artificial Beta Cell Algorithms but Their Parameter Values Are Important in Automated Glucose Control of Insulin-dependent Diabetes. Trans Am Soc Artif Intern Organs. 1983;29:488-91. PubMed PMID: 6673274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Not the artificial beta cell algorithms but their parameter values are important in automated glucose control of insulin-dependent diabetes. AU - Fischer,U, AU - Jutzi,E, AU - Albrecht,G, AU - Abel,P, AU - Salzsieder,E, AU - Freyse,E J, AU - Detscheff,W, AU - Lemke,K, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 488 EP - 91 JF - Transactions - American Society for Artificial Internal Organs JO - Trans Am Soc Artif Intern Organs VL - 29 N2 - The blood glucose responses of diabetic dogs on the ABC are nearly identical if different algorithms, but equivalent sets of parameters are used to control the glucose-dependent insulin infusion. There are however some differences in the insulin doses applied, which obviously result from different response kinetics of the particular formula to the minor BG oscillations that always occur. In the practical application of closed-loop systems the control constants should be individually estimated on the basis of certain controlled plant characteristics. For use in patients the checking and modeling systems still have to be simplified. The limits of the study, i.e. the fact that normoglycemia was restored for a short time only using the IV instead of the physiological portal route, remain the subject of further investigation. SN - 0066-0078 UR - https://www.unboundmedicine.com/medline/citation/6673274/Not_the_artificial_beta_cell_algorithms_but_their_parameter_values_are_important_in_automated_glucose_control_of_insulin_dependent_diabetes_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=6673274.ui DB - PRIME DP - Unbound Medicine ER -