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Diazoxide vs labetalol: a cross-over comparison of short-term effects in hypertension.
Int J Clin Pharmacol Res. 1983; 3(1):47-54.IJ

Abstract

In a randomized cross-over study the acute effects of intravenous labetalol (1-2 mg/kg; mean dose 86.5 mg) were compared with those of diazoxide (3-5 mg/kg; mean dose 253.8 mg) in 13 severely hypertensive patients with diastolic blood pressure above 110 mm Hg (36.3 kPa) and a mean arterial pressure (MAP) of 165.4 mm Hg (22.0 kPa). Within five minutes following injection of both drugs an immediate fall in arterial pressure was observed (P less than 0.05), which was even more pronounced during subsequent minutes (P less than 0.01). The reduction in MAP after 30 minutes averaged 20% (P less than 0.01), with no significant differences between the drugs under trial or administration schedules. Diazoxide did not increase the heart rate as much as expected (P greater than 0.10), while labetalol slowed it down moderately but significantly (P less than 0.05). There were no notable changes in the blood levels of glucose and potassium and no particular side-effects were observed. It is concluded that the acute effects of intravenous labetalol are comparable to those of diazoxide and that labetalol can be used with advantage as a complemental alternative to diazoxide in the emergency treatment of some hypertensive crises.

Authors

Rumboldt Z
No affiliation info available
Bagatin J
No affiliation info available
Vidovic A
No affiliation info available

MeSH

AdultAgedBlood GlucoseBlood PressureDiazoxideDrug EvaluationEthanolaminesFemaleHeart RateHumansHypertensionLabetalolMaleMiddle AgedPotassiumRandom Allocation

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6679507

Citation

Rumboldt, Z, et al. "Diazoxide Vs Labetalol: a Cross-over Comparison of Short-term Effects in Hypertension." International Journal of Clinical Pharmacology Research, vol. 3, no. 1, 1983, pp. 47-54.
Rumboldt Z, Bagatin J, Vidovic A. Diazoxide vs labetalol: a cross-over comparison of short-term effects in hypertension. Int J Clin Pharmacol Res. 1983;3(1):47-54.
Rumboldt, Z., Bagatin, J., & Vidovic, A. (1983). Diazoxide vs labetalol: a cross-over comparison of short-term effects in hypertension. International Journal of Clinical Pharmacology Research, 3(1), 47-54.
Rumboldt Z, Bagatin J, Vidovic A. Diazoxide Vs Labetalol: a Cross-over Comparison of Short-term Effects in Hypertension. Int J Clin Pharmacol Res. 1983;3(1):47-54. PubMed PMID: 6679507.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diazoxide vs labetalol: a cross-over comparison of short-term effects in hypertension. AU - Rumboldt,Z, AU - Bagatin,J, AU - Vidovic,A, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 47 EP - 54 JF - International journal of clinical pharmacology research JO - Int J Clin Pharmacol Res VL - 3 IS - 1 N2 - In a randomized cross-over study the acute effects of intravenous labetalol (1-2 mg/kg; mean dose 86.5 mg) were compared with those of diazoxide (3-5 mg/kg; mean dose 253.8 mg) in 13 severely hypertensive patients with diastolic blood pressure above 110 mm Hg (36.3 kPa) and a mean arterial pressure (MAP) of 165.4 mm Hg (22.0 kPa). Within five minutes following injection of both drugs an immediate fall in arterial pressure was observed (P less than 0.05), which was even more pronounced during subsequent minutes (P less than 0.01). The reduction in MAP after 30 minutes averaged 20% (P less than 0.01), with no significant differences between the drugs under trial or administration schedules. Diazoxide did not increase the heart rate as much as expected (P greater than 0.10), while labetalol slowed it down moderately but significantly (P less than 0.05). There were no notable changes in the blood levels of glucose and potassium and no particular side-effects were observed. It is concluded that the acute effects of intravenous labetalol are comparable to those of diazoxide and that labetalol can be used with advantage as a complemental alternative to diazoxide in the emergency treatment of some hypertensive crises. SN - 0251-1649 UR - https://www.unboundmedicine.com/medline/citation/6679507/Diazoxide_vs_labetalol:_a_cross_over_comparison_of_short_term_effects_in_hypertension_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -