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Quantitative aspects of IgD and secretory immunoglobulins in middle ear effusions.
Int J Pediatr Otorhinolaryngol. 1983 Dec; 6(3):247-53.IJ

Abstract

Levels of the true secretory immunoglobulins, secretory IgA (SIgA) and secretory IgM (SIgM) were determined in middle ear effusions (MEEs) from children with secretory otitis media (SOM) and correlated to the MEE levels of IgD. Double sandwich enzyme-linked immunosorbent assays (ELISA) were used for the quantitative determinations. The levels of SIgM were expressed arbitrarily in units using a nasopharyngeal secretion pool as a standard. The quantitative data substantiated a local synthesis of IgD to the middle ear cavity. In 8/45 MEEs more than 600 mg/l of IgD could be calculated and between 70% and 98% could be considered to be locally produced. A statistically significant correlation was observed between SIgA and SIgM. The results are discussed in the context of the possibility that IgD plasma cells located in the middle ear cavity may primarily originate from the nasopharyngeal tonsils.

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Publisher Full Text

Authors

Sørensen CH
No affiliation info available

MeSH

ChildChild, PreschoolEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin A, SecretoryImmunoglobulin DImmunoglobulin MOtitis MediaOtitis Media with Effusion

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6687122

Citation

Sørensen, C H.. "Quantitative Aspects of IgD and Secretory Immunoglobulins in Middle Ear Effusions." International Journal of Pediatric Otorhinolaryngology, vol. 6, no. 3, 1983, pp. 247-53.
Sørensen CH. Quantitative aspects of IgD and secretory immunoglobulins in middle ear effusions. Int J Pediatr Otorhinolaryngol. 1983;6(3):247-53.
Sørensen, C. H. (1983). Quantitative aspects of IgD and secretory immunoglobulins in middle ear effusions. International Journal of Pediatric Otorhinolaryngology, 6(3), 247-53.
Sørensen CH. Quantitative Aspects of IgD and Secretory Immunoglobulins in Middle Ear Effusions. Int J Pediatr Otorhinolaryngol. 1983;6(3):247-53. PubMed PMID: 6687122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative aspects of IgD and secretory immunoglobulins in middle ear effusions. A1 - Sørensen,C H, PY - 1983/12/1/pubmed PY - 1983/12/1/medline PY - 1983/12/1/entrez SP - 247 EP - 53 JF - International journal of pediatric otorhinolaryngology JO - Int J Pediatr Otorhinolaryngol VL - 6 IS - 3 N2 - Levels of the true secretory immunoglobulins, secretory IgA (SIgA) and secretory IgM (SIgM) were determined in middle ear effusions (MEEs) from children with secretory otitis media (SOM) and correlated to the MEE levels of IgD. Double sandwich enzyme-linked immunosorbent assays (ELISA) were used for the quantitative determinations. The levels of SIgM were expressed arbitrarily in units using a nasopharyngeal secretion pool as a standard. The quantitative data substantiated a local synthesis of IgD to the middle ear cavity. In 8/45 MEEs more than 600 mg/l of IgD could be calculated and between 70% and 98% could be considered to be locally produced. A statistically significant correlation was observed between SIgA and SIgM. The results are discussed in the context of the possibility that IgD plasma cells located in the middle ear cavity may primarily originate from the nasopharyngeal tonsils. SN - 0165-5876 UR - https://www.unboundmedicine.com/medline/citation/6687122/Quantitative_aspects_of_IgD_and_secretory_immunoglobulins_in_middle_ear_effusions_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5876(83)80126-8 DB - PRIME DP - Unbound Medicine ER -