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Anticholinergic action of pirenzepine (Gastrozepin) on isolated gastrointestinal tract smooth muscles.
Methods Find Exp Clin Pharmacol. 1983; 5(3):171-5.MF

Abstract

The effects of pirenzepine, a new anti-ulcer drug, have been examined on acetylcholine (ACh)-induced contractions of the guinea-pig isolated ileum, rat colon, rainbow lizard rectum, and chick isolated oesophagus. Pirenzepine (10(-9)-10(-6) M), like atropine (2.5 x 10(-10)-10(-6) M) competitively blocked the contractile effects of acetylcholine on all the isolated gastrointestinal tract smooth muscles examined. The pA2 values for pirenzepine and atropine against acetylcholine on all the muscle preparations were not significantly different (P greater than 0.05). It is concluded that the anti-ulcer action of pirenzepine might be due, at least in part, to its (anticholinergic) muscarinic cholinoceptor blocking activity.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6688455

Citation

Ojewole, J A.. "Anticholinergic Action of Pirenzepine (Gastrozepin) On Isolated Gastrointestinal Tract Smooth Muscles." Methods and Findings in Experimental and Clinical Pharmacology, vol. 5, no. 3, 1983, pp. 171-5.
Ojewole JA. Anticholinergic action of pirenzepine (Gastrozepin) on isolated gastrointestinal tract smooth muscles. Methods Find Exp Clin Pharmacol. 1983;5(3):171-5.
Ojewole, J. A. (1983). Anticholinergic action of pirenzepine (Gastrozepin) on isolated gastrointestinal tract smooth muscles. Methods and Findings in Experimental and Clinical Pharmacology, 5(3), 171-5.
Ojewole JA. Anticholinergic Action of Pirenzepine (Gastrozepin) On Isolated Gastrointestinal Tract Smooth Muscles. Methods Find Exp Clin Pharmacol. 1983;5(3):171-5. PubMed PMID: 6688455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anticholinergic action of pirenzepine (Gastrozepin) on isolated gastrointestinal tract smooth muscles. A1 - Ojewole,J A, PY - 1983/1/1/pubmed PY - 1983/1/1/medline PY - 1983/1/1/entrez SP - 171 EP - 5 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 5 IS - 3 N2 - The effects of pirenzepine, a new anti-ulcer drug, have been examined on acetylcholine (ACh)-induced contractions of the guinea-pig isolated ileum, rat colon, rainbow lizard rectum, and chick isolated oesophagus. Pirenzepine (10(-9)-10(-6) M), like atropine (2.5 x 10(-10)-10(-6) M) competitively blocked the contractile effects of acetylcholine on all the isolated gastrointestinal tract smooth muscles examined. The pA2 values for pirenzepine and atropine against acetylcholine on all the muscle preparations were not significantly different (P greater than 0.05). It is concluded that the anti-ulcer action of pirenzepine might be due, at least in part, to its (anticholinergic) muscarinic cholinoceptor blocking activity. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/6688455/Anticholinergic_action_of_pirenzepine__Gastrozepin__on_isolated_gastrointestinal_tract_smooth_muscles_ DB - PRIME DP - Unbound Medicine ER -