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Effect of inhibition of thromboxane production on the leukotriene D4-mediated bronchoconstriction in the guinea pig.
Prostaglandins. 1983 Aug; 26(2):197-206.P

Abstract

Leukotriene D4 (LTD4) administered intravenously to anesthetized, spontaneously breathing guinea pigs elicited decreases in dynamic lung compliance (Cdyn) and airway conductance (GAW) with a maximal response achieved at 0.5 min. Simultaneously, plasma levels of the thromboxane metabolite, TxB2, and the prostacyclin metabolite, 6-keto-PGF1 alpha, increased 10-fold over pre-LTD4 levels. Pretreatment of the guinea pigs with meclofenamic acid delayed the onset of the LTD4-induced bronchoconstriction, antagonized the magnitude of the decreases in Cdyn and GAW, and blocked the increase in plasma TxB2 and 6-keto-PGF1 alpha levels. The thromboxane synthetase inhibitor, UK 37,248, suppressed the LTD4-induced bronchoconstriction, while it completely blocked TxB2 production without significantly affecting 6-keto-PGF1 alpha. The SRS-A end organ antagonist, FPL 55712, blocked both the LTD4-induced bronchoconstriction and the production of the arachidonic acid metabolites. These results suggest that thromboxane A2 plays an important role in mediating part of the bronchoconstriction elicited by intravenously administered LTD4 in the guinea pig.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6689082

Citation

Muccitelli, R M., et al. "Effect of Inhibition of Thromboxane Production On the Leukotriene D4-mediated Bronchoconstriction in the Guinea Pig." Prostaglandins, vol. 26, no. 2, 1983, pp. 197-206.
Muccitelli RM, Osborn RR, Weichman BM. Effect of inhibition of thromboxane production on the leukotriene D4-mediated bronchoconstriction in the guinea pig. Prostaglandins. 1983;26(2):197-206.
Muccitelli, R. M., Osborn, R. R., & Weichman, B. M. (1983). Effect of inhibition of thromboxane production on the leukotriene D4-mediated bronchoconstriction in the guinea pig. Prostaglandins, 26(2), 197-206.
Muccitelli RM, Osborn RR, Weichman BM. Effect of Inhibition of Thromboxane Production On the Leukotriene D4-mediated Bronchoconstriction in the Guinea Pig. Prostaglandins. 1983;26(2):197-206. PubMed PMID: 6689082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of inhibition of thromboxane production on the leukotriene D4-mediated bronchoconstriction in the guinea pig. AU - Muccitelli,R M, AU - Osborn,R R, AU - Weichman,B M, PY - 1983/8/1/pubmed PY - 1983/8/1/medline PY - 1983/8/1/entrez SP - 197 EP - 206 JF - Prostaglandins JO - Prostaglandins VL - 26 IS - 2 N2 - Leukotriene D4 (LTD4) administered intravenously to anesthetized, spontaneously breathing guinea pigs elicited decreases in dynamic lung compliance (Cdyn) and airway conductance (GAW) with a maximal response achieved at 0.5 min. Simultaneously, plasma levels of the thromboxane metabolite, TxB2, and the prostacyclin metabolite, 6-keto-PGF1 alpha, increased 10-fold over pre-LTD4 levels. Pretreatment of the guinea pigs with meclofenamic acid delayed the onset of the LTD4-induced bronchoconstriction, antagonized the magnitude of the decreases in Cdyn and GAW, and blocked the increase in plasma TxB2 and 6-keto-PGF1 alpha levels. The thromboxane synthetase inhibitor, UK 37,248, suppressed the LTD4-induced bronchoconstriction, while it completely blocked TxB2 production without significantly affecting 6-keto-PGF1 alpha. The SRS-A end organ antagonist, FPL 55712, blocked both the LTD4-induced bronchoconstriction and the production of the arachidonic acid metabolites. These results suggest that thromboxane A2 plays an important role in mediating part of the bronchoconstriction elicited by intravenously administered LTD4 in the guinea pig. SN - 0090-6980 UR - https://www.unboundmedicine.com/medline/citation/6689082/Effect_of_inhibition_of_thromboxane_production_on_the_leukotriene_D4_mediated_bronchoconstriction_in_the_guinea_pig_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0090-6980(83)90088-6 DB - PRIME DP - Unbound Medicine ER -