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MDA: a psychoactive agent with dual stimulus effects.
Life Sci. 1984 Jan 23; 34(4):379-83.LS

Abstract

Rats were trained to discriminate injections of either (+)-amphetamine (1.0 mg/kg) or racemic MDA (1.5 mg/kg) from saline in a two-lever drug discrimination task. After stable discrimination performances (greater than 85%) were attained in each group, stimulus generalization studies were conducted. The amphetamine-stimulus generalized to MDA, but not to the hallucinogenic agent DOM; the MDA-stimulus generalized to both amphetamine and DOM. Taken together with our previous finding that DOM-stimulus generalization occurs to MDA but not to amphetamine, the present study suggests that MDA is capable of producing dual stimulus effects in animals. In addition to these salient features, the results of this study also have an impact on stimulus specificity, and further emphasize the importance of thorough dose-response relationships as related to tests of stimulus generalization.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6694526

Citation

Glennon, R A., and R Young. "MDA: a Psychoactive Agent With Dual Stimulus Effects." Life Sciences, vol. 34, no. 4, 1984, pp. 379-83.
Glennon RA, Young R. MDA: a psychoactive agent with dual stimulus effects. Life Sci. 1984;34(4):379-83.
Glennon, R. A., & Young, R. (1984). MDA: a psychoactive agent with dual stimulus effects. Life Sciences, 34(4), 379-83.
Glennon RA, Young R. MDA: a Psychoactive Agent With Dual Stimulus Effects. Life Sci. 1984 Jan 23;34(4):379-83. PubMed PMID: 6694526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MDA: a psychoactive agent with dual stimulus effects. AU - Glennon,R A, AU - Young,R, PY - 1984/1/23/pubmed PY - 1984/1/23/medline PY - 1984/1/23/entrez SP - 379 EP - 83 JF - Life sciences JO - Life Sci VL - 34 IS - 4 N2 - Rats were trained to discriminate injections of either (+)-amphetamine (1.0 mg/kg) or racemic MDA (1.5 mg/kg) from saline in a two-lever drug discrimination task. After stable discrimination performances (greater than 85%) were attained in each group, stimulus generalization studies were conducted. The amphetamine-stimulus generalized to MDA, but not to the hallucinogenic agent DOM; the MDA-stimulus generalized to both amphetamine and DOM. Taken together with our previous finding that DOM-stimulus generalization occurs to MDA but not to amphetamine, the present study suggests that MDA is capable of producing dual stimulus effects in animals. In addition to these salient features, the results of this study also have an impact on stimulus specificity, and further emphasize the importance of thorough dose-response relationships as related to tests of stimulus generalization. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/6694526/MDA:_a_psychoactive_agent_with_dual_stimulus_effects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0024-3205(84)90627-1 DB - PRIME DP - Unbound Medicine ER -