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Breast cancer and oral contraceptive use.
Am J Epidemiol 1984; 119(2):167-76AJ

Abstract

The risk of breast cancer in relation to oral contraceptive use was evaluated in a case-control study of 1191 patients with breast cancer and 5026 control patients. For ever-use compared with never-use, the estimated relative risk of breast cancer was 1.0 (95% confidence interval 0.9-1.2). Use of oral contraceptives for five or more years was not associated with breast cancer, regardless of whether use had ended as much as 10 or more years previously, or more recently. Within categories of women whose baseline risk was elevated, including nulligravidae, premenopausal women, and those with benign breast disease or history of breast cancer in first-degree relatives, the relative risk estimates for five or more years of oral contraceptive use approximated 1.0. For any use before first pregnancy, the relative risk estimate was 1.3, and for use lasting three or more years it was 0.9. These data suggest that long-term oral contraceptive use does not increase the risk of breast cancer even after a latent interval in excess of one decade; nor do oral contraceptives appear to increase the risk within categories of women at relatively high baseline risk.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6695896

Citation

Rosenberg, L, et al. "Breast Cancer and Oral Contraceptive Use." American Journal of Epidemiology, vol. 119, no. 2, 1984, pp. 167-76.
Rosenberg L, Miller DR, Kaufman DW, et al. Breast cancer and oral contraceptive use. Am J Epidemiol. 1984;119(2):167-76.
Rosenberg, L., Miller, D. R., Kaufman, D. W., Helmrich, S. P., Stolley, P. D., Schottenfeld, D., & Shapiro, S. (1984). Breast cancer and oral contraceptive use. American Journal of Epidemiology, 119(2), pp. 167-76.
Rosenberg L, et al. Breast Cancer and Oral Contraceptive Use. Am J Epidemiol. 1984;119(2):167-76. PubMed PMID: 6695896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast cancer and oral contraceptive use. AU - Rosenberg,L, AU - Miller,D R, AU - Kaufman,D W, AU - Helmrich,S P, AU - Stolley,P D, AU - Schottenfeld,D, AU - Shapiro,S, PY - 1984/2/1/pubmed PY - 1984/2/1/medline PY - 1984/2/1/entrez KW - Breast Cancer--etiology KW - Cancer KW - Clinical Research KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--side effects KW - Diseases KW - Family Planning KW - Neoplasms KW - Oral Contraceptives--side effects KW - Population At Risk KW - Research Methodology SP - 167 EP - 76 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 119 IS - 2 N2 - The risk of breast cancer in relation to oral contraceptive use was evaluated in a case-control study of 1191 patients with breast cancer and 5026 control patients. For ever-use compared with never-use, the estimated relative risk of breast cancer was 1.0 (95% confidence interval 0.9-1.2). Use of oral contraceptives for five or more years was not associated with breast cancer, regardless of whether use had ended as much as 10 or more years previously, or more recently. Within categories of women whose baseline risk was elevated, including nulligravidae, premenopausal women, and those with benign breast disease or history of breast cancer in first-degree relatives, the relative risk estimates for five or more years of oral contraceptive use approximated 1.0. For any use before first pregnancy, the relative risk estimate was 1.3, and for use lasting three or more years it was 0.9. These data suggest that long-term oral contraceptive use does not increase the risk of breast cancer even after a latent interval in excess of one decade; nor do oral contraceptives appear to increase the risk within categories of women at relatively high baseline risk. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/6695896/Breast_cancer_and_oral_contraceptive_use_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a113735 DB - PRIME DP - Unbound Medicine ER -