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Alopecia areata: light and electron microscopic pathology of the regrowing white hair.
Br J Dermatol. 1984 Feb; 110(2):155-62.BJ

Abstract

Light and electron microscopic studies have been carried out on fifteen regrowing white anagen hair follicles from seven patients with alopecia areata. Seven bulbs showed evidence of cell injury that was concentrated in cortical keratocytes. Lower bulb matrix cells appeared undamaged though in six bulbs apoptotic degeneration was seen in the lower bulb keratocytes, perhaps indicating early catagen transformation. Melanocytes were identified in all the bulbs except those from one patient. The number of melanocytes and their melanization were much less than in the normal pigmented follicle, and pigment transfer was rarely seen. It is proposed that alopecia areata is a disease of differentiating cortical keratocytes. The failure of pigmentation in the regrowing white hair may be post-inflammatory, but the various other pigmentary features of alopecia areata, especially the sparing of senile white hairs, suggest that pigmentary mechanisms in the hair bulb are of primary importance in the pathogenesis of this disorder.

Links

Publisher Full Text

Authors

Messenger AG
No affiliation info available
Bleehen SS
No affiliation info available

MeSH

AdultAlopecia AreataFemaleHairHair ColorHumansMaleMelanocytesMicroscopy, ElectronMiddle Aged

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6696834

Citation

Messenger, A G., and S S. Bleehen. "Alopecia Areata: Light and Electron Microscopic Pathology of the Regrowing White Hair." The British Journal of Dermatology, vol. 110, no. 2, 1984, pp. 155-62.
Messenger AG, Bleehen SS. Alopecia areata: light and electron microscopic pathology of the regrowing white hair. Br J Dermatol. 1984;110(2):155-62.
Messenger, A. G., & Bleehen, S. S. (1984). Alopecia areata: light and electron microscopic pathology of the regrowing white hair. The British Journal of Dermatology, 110(2), 155-62.
Messenger AG, Bleehen SS. Alopecia Areata: Light and Electron Microscopic Pathology of the Regrowing White Hair. Br J Dermatol. 1984;110(2):155-62. PubMed PMID: 6696834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alopecia areata: light and electron microscopic pathology of the regrowing white hair. AU - Messenger,A G, AU - Bleehen,S S, PY - 1984/2/1/pubmed PY - 1984/2/1/medline PY - 1984/2/1/entrez SP - 155 EP - 62 JF - The British journal of dermatology JO - Br J Dermatol VL - 110 IS - 2 N2 - Light and electron microscopic studies have been carried out on fifteen regrowing white anagen hair follicles from seven patients with alopecia areata. Seven bulbs showed evidence of cell injury that was concentrated in cortical keratocytes. Lower bulb matrix cells appeared undamaged though in six bulbs apoptotic degeneration was seen in the lower bulb keratocytes, perhaps indicating early catagen transformation. Melanocytes were identified in all the bulbs except those from one patient. The number of melanocytes and their melanization were much less than in the normal pigmented follicle, and pigment transfer was rarely seen. It is proposed that alopecia areata is a disease of differentiating cortical keratocytes. The failure of pigmentation in the regrowing white hair may be post-inflammatory, but the various other pigmentary features of alopecia areata, especially the sparing of senile white hairs, suggest that pigmentary mechanisms in the hair bulb are of primary importance in the pathogenesis of this disorder. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/6696834/Alopecia_areata:_light_and_electron_microscopic_pathology_of_the_regrowing_white_hair_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1984&volume=110&issue=2&spage=155 DB - PRIME DP - Unbound Medicine ER -