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Thermal transitions of red blood cell deformability. Correlation with membrane rheological properties.
Biochim Biophys Acta 1984; 769(2):461-70BB

Abstract

Red blood cell deformability has been studied by the initial filtration flow rate as a function of temperature. The well-known transition at 49-50 degrees C (probably due to spectrin denaturation) is shown. Another transition is demonstrated around 18 degrees C (the cell becomes stiffer below this temperature range). The erythrocyte membranes prepared by a mild dialysis technique have the same deformability as intact erythrocytes at room temperature; they also show the same low-temperature transition. No such transition has been found for hemoglobin solutions of viscosity 30 g X dl-1. It is interesting to compare these results with those obtained by other methods which measure the properties of natural or artificial lipid membranes and which also demonstrate a thermal transition at 15-20 degrees C. Therefore, the deformability of intact normal erythrocytes seems to depend mainly on the rheological properties of the membrane.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6696894

Citation

Hanss, M, and D Koutsouris. "Thermal Transitions of Red Blood Cell Deformability. Correlation With Membrane Rheological Properties." Biochimica Et Biophysica Acta, vol. 769, no. 2, 1984, pp. 461-70.
Hanss M, Koutsouris D. Thermal transitions of red blood cell deformability. Correlation with membrane rheological properties. Biochim Biophys Acta. 1984;769(2):461-70.
Hanss, M., & Koutsouris, D. (1984). Thermal transitions of red blood cell deformability. Correlation with membrane rheological properties. Biochimica Et Biophysica Acta, 769(2), pp. 461-70.
Hanss M, Koutsouris D. Thermal Transitions of Red Blood Cell Deformability. Correlation With Membrane Rheological Properties. Biochim Biophys Acta. 1984 Jan 25;769(2):461-70. PubMed PMID: 6696894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thermal transitions of red blood cell deformability. Correlation with membrane rheological properties. AU - Hanss,M, AU - Koutsouris,D, PY - 1984/1/25/pubmed PY - 1984/1/25/medline PY - 1984/1/25/entrez SP - 461 EP - 70 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 769 IS - 2 N2 - Red blood cell deformability has been studied by the initial filtration flow rate as a function of temperature. The well-known transition at 49-50 degrees C (probably due to spectrin denaturation) is shown. Another transition is demonstrated around 18 degrees C (the cell becomes stiffer below this temperature range). The erythrocyte membranes prepared by a mild dialysis technique have the same deformability as intact erythrocytes at room temperature; they also show the same low-temperature transition. No such transition has been found for hemoglobin solutions of viscosity 30 g X dl-1. It is interesting to compare these results with those obtained by other methods which measure the properties of natural or artificial lipid membranes and which also demonstrate a thermal transition at 15-20 degrees C. Therefore, the deformability of intact normal erythrocytes seems to depend mainly on the rheological properties of the membrane. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/6696894/Thermal_transitions_of_red_blood_cell_deformability__Correlation_with_membrane_rheological_properties_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0005-2736(84)90331-6 DB - PRIME DP - Unbound Medicine ER -