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Steroid hormone receptors, protein, and DNA in erector spinae muscle from scoliotic patients.

Abstract

To investigate the possible influence of steroid hormones on the back muscles of scoliotic patients, steroid receptors, protein, and DNA were analyzed in muscle from 20 patients of both sexes, at different ages, and with different clinical diagnoses. Androgen and glucocorticoid receptors, but no estrogen receptors, were found. The androgen and glucocorticoid receptors had binding characteristics similar to those of corresponding receptors in other mammalian skeletal muscle, including that of humans. Whereas the concentration of androgen receptors was similar on both sides of the curve, the concentration of glucocorticoid receptors per gram of tissue (wet weight) was higher on the convex side. There were no side differences in steroid receptor content when measured per milligram of protein or per milligram of DNA. The concentrations of protein and DNA were higher on the convex than on the concave side and resulted in lower protein/DNA ratios on the former side indicating smaller "cell units" in muscle on the convex side. These data suggest that the side differences in scoliotic erector spinae muscle for these growth parameters can be secondary to the reported different distribution of fiber types on both sides, but they can also be due to a difference in growth of the muscle cells on the two sides.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6697588

Citation

Saatok, T, et al. "Steroid Hormone Receptors, Protein, and DNA in Erector Spinae Muscle From Scoliotic Patients." Clinical Orthopaedics and Related Research, 1984, pp. 197-207.
Saatok T, Dahlberg E, Bylund P, et al. Steroid hormone receptors, protein, and DNA in erector spinae muscle from scoliotic patients. Clin Orthop Relat Res. 1984.
Saatok, T., Dahlberg, E., Bylund, P., Eriksson, E., & Gustafsson, J. A. (1984). Steroid hormone receptors, protein, and DNA in erector spinae muscle from scoliotic patients. Clinical Orthopaedics and Related Research, (183), 197-207.
Saatok T, et al. Steroid Hormone Receptors, Protein, and DNA in Erector Spinae Muscle From Scoliotic Patients. Clin Orthop Relat Res. 1984;(183)197-207. PubMed PMID: 6697588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steroid hormone receptors, protein, and DNA in erector spinae muscle from scoliotic patients. AU - Saatok,T, AU - Dahlberg,E, AU - Bylund,P, AU - Eriksson,E, AU - Gustafsson,J A, PY - 1984/3/1/pubmed PY - 1984/3/1/medline PY - 1984/3/1/entrez SP - 197 EP - 207 JF - Clinical orthopaedics and related research JO - Clin Orthop Relat Res IS - 183 N2 - To investigate the possible influence of steroid hormones on the back muscles of scoliotic patients, steroid receptors, protein, and DNA were analyzed in muscle from 20 patients of both sexes, at different ages, and with different clinical diagnoses. Androgen and glucocorticoid receptors, but no estrogen receptors, were found. The androgen and glucocorticoid receptors had binding characteristics similar to those of corresponding receptors in other mammalian skeletal muscle, including that of humans. Whereas the concentration of androgen receptors was similar on both sides of the curve, the concentration of glucocorticoid receptors per gram of tissue (wet weight) was higher on the convex side. There were no side differences in steroid receptor content when measured per milligram of protein or per milligram of DNA. The concentrations of protein and DNA were higher on the convex than on the concave side and resulted in lower protein/DNA ratios on the former side indicating smaller "cell units" in muscle on the convex side. These data suggest that the side differences in scoliotic erector spinae muscle for these growth parameters can be secondary to the reported different distribution of fiber types on both sides, but they can also be due to a difference in growth of the muscle cells on the two sides. SN - 0009-921X UR - https://www.unboundmedicine.com/medline/citation/6697588/Steroid_hormone_receptors_protein_and_DNA_in_erector_spinae_muscle_from_scoliotic_patients_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=6697588.ui DB - PRIME DP - Unbound Medicine ER -