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Gallbladder disease: risk factor for colorectal carcinoma?
J Clin Gastroenterol. 1984 Feb; 6(1):51-5.JC

Abstract

The relation between gallbladder disease and the risk of colorectal carcinoma (CRC) is examined in light of 864 consecutive adult postmortem examinations analyzed for significant associations between the state of the gallbladder (normal, cholelithiasis, and cholecystectomy) and the presence of colorectal carcinoma. Our findings supported the known association between female sex and gallbladder disease (p = 0.02) and revealed a significant association between cholelithiasis and/or cholecystectomy and colorectal cancer (p less than 0.02). The frequency of CRC was higher in patients who had a cholecystectomy than in those still with stones, but this difference was not statistically significant. The data suggests a sex-linked dependence between the state of gallbladder and CRC. However, the proper statistical test for this dependence was not significant (p less than 0.25), no doubt as a result of the relatively small amount of data for persons with gallbladder disease. We conclude that the state of gallbladder may modify the risk for colorectal carcinoma.

Authors

Allende HD
No affiliation info available
Ona FV
No affiliation info available
Davis HT
No affiliation info available

MeSH

CholecystectomyCholelithiasisColonic NeoplasmsFemaleHumansMalePostoperative ComplicationsRectal NeoplasmsRiskSex Factors

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6699393

Citation

Allende, H D., et al. "Gallbladder Disease: Risk Factor for Colorectal Carcinoma?" Journal of Clinical Gastroenterology, vol. 6, no. 1, 1984, pp. 51-5.
Allende HD, Ona FV, Davis HT. Gallbladder disease: risk factor for colorectal carcinoma? J Clin Gastroenterol. 1984;6(1):51-5.
Allende, H. D., Ona, F. V., & Davis, H. T. (1984). Gallbladder disease: risk factor for colorectal carcinoma? Journal of Clinical Gastroenterology, 6(1), 51-5.
Allende HD, Ona FV, Davis HT. Gallbladder Disease: Risk Factor for Colorectal Carcinoma. J Clin Gastroenterol. 1984;6(1):51-5. PubMed PMID: 6699393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gallbladder disease: risk factor for colorectal carcinoma? AU - Allende,H D, AU - Ona,F V, AU - Davis,H T, PY - 1984/2/1/pubmed PY - 1984/2/1/medline PY - 1984/2/1/entrez SP - 51 EP - 5 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 6 IS - 1 N2 - The relation between gallbladder disease and the risk of colorectal carcinoma (CRC) is examined in light of 864 consecutive adult postmortem examinations analyzed for significant associations between the state of the gallbladder (normal, cholelithiasis, and cholecystectomy) and the presence of colorectal carcinoma. Our findings supported the known association between female sex and gallbladder disease (p = 0.02) and revealed a significant association between cholelithiasis and/or cholecystectomy and colorectal cancer (p less than 0.02). The frequency of CRC was higher in patients who had a cholecystectomy than in those still with stones, but this difference was not statistically significant. The data suggests a sex-linked dependence between the state of gallbladder and CRC. However, the proper statistical test for this dependence was not significant (p less than 0.25), no doubt as a result of the relatively small amount of data for persons with gallbladder disease. We conclude that the state of gallbladder may modify the risk for colorectal carcinoma. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/6699393/Gallbladder_disease:_risk_factor_for_colorectal_carcinoma L2 - https://medlineplus.gov/gallstones.html DB - PRIME DP - Unbound Medicine ER -