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Prevention of acute mountain sickness by dexamethasone.
N Engl J Med. 1984 Mar 15; 310(11):683-6.NEJM

Abstract

Acute mountain sickness is a syndrome that occurs when unacclimatized persons ascend rapidly to high altitudes. It is postulated that cerebral edema causes its symptoms. Since dexamethasone is useful in treating some forms of cerebral edema, we investigated its role in the prevention of acute mountain sickness. Using a double-blind crossover design, we exposed eight young men to a simulated altitude of 4570 m (15,000 ft) on two occasions. By random assignment, each subject received dexamethasone (4 mg every 6 hours) or placebo for 48 hours before and throughout the 42-hour exposure. The presence of symptoms of acute mountain sickness was established by two methods: a questionnaire and an interview by a physician. Dexamethasone significantly reduced the symptoms of acute mountain sickness. During dexamethasone treatment, the cerebral-symptom score (mean +/- S.E.) decreased from 1.09 +/- 0.18 to 0.26 +/- 0.08, and the respiratory-symptom score decreased from 0.64 +/- 0.09 to 0.31 +/- 0.06 (both, P less than 0.05). As judged by the interviewing physician, the symptom score decreased from 1.10 +/- 0.11 to 0.28 +/- 0.07 (P = 0.01). We conclude that dexamethasone may be effective in preventing the symptoms of acute mountain sickness.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

6700643

Citation

Johnson, T S., et al. "Prevention of Acute Mountain Sickness By Dexamethasone." The New England Journal of Medicine, vol. 310, no. 11, 1984, pp. 683-6.
Johnson TS, Rock PB, Fulco CS, et al. Prevention of acute mountain sickness by dexamethasone. N Engl J Med. 1984;310(11):683-6.
Johnson, T. S., Rock, P. B., Fulco, C. S., Trad, L. A., Spark, R. F., & Maher, J. T. (1984). Prevention of acute mountain sickness by dexamethasone. The New England Journal of Medicine, 310(11), 683-6.
Johnson TS, et al. Prevention of Acute Mountain Sickness By Dexamethasone. N Engl J Med. 1984 Mar 15;310(11):683-6. PubMed PMID: 6700643.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of acute mountain sickness by dexamethasone. AU - Johnson,T S, AU - Rock,P B, AU - Fulco,C S, AU - Trad,L A, AU - Spark,R F, AU - Maher,J T, PY - 1984/3/15/pubmed PY - 1984/3/15/medline PY - 1984/3/15/entrez SP - 683 EP - 6 JF - The New England journal of medicine JO - N. Engl. J. Med. VL - 310 IS - 11 N2 - Acute mountain sickness is a syndrome that occurs when unacclimatized persons ascend rapidly to high altitudes. It is postulated that cerebral edema causes its symptoms. Since dexamethasone is useful in treating some forms of cerebral edema, we investigated its role in the prevention of acute mountain sickness. Using a double-blind crossover design, we exposed eight young men to a simulated altitude of 4570 m (15,000 ft) on two occasions. By random assignment, each subject received dexamethasone (4 mg every 6 hours) or placebo for 48 hours before and throughout the 42-hour exposure. The presence of symptoms of acute mountain sickness was established by two methods: a questionnaire and an interview by a physician. Dexamethasone significantly reduced the symptoms of acute mountain sickness. During dexamethasone treatment, the cerebral-symptom score (mean +/- S.E.) decreased from 1.09 +/- 0.18 to 0.26 +/- 0.08, and the respiratory-symptom score decreased from 0.64 +/- 0.09 to 0.31 +/- 0.06 (both, P less than 0.05). As judged by the interviewing physician, the symptom score decreased from 1.10 +/- 0.11 to 0.28 +/- 0.07 (P = 0.01). We conclude that dexamethasone may be effective in preventing the symptoms of acute mountain sickness. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/6700643/full_citation L2 - http://www.nejm.org/doi/full/10.1056/NEJM198403153101103?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -