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[Bioavailability of codeine and paracetamol in a combination preparation following oral and rectal administration].
Fortschr Med. 1984 Feb 16; 102(7):173-8.FM

Abstract

The plasma concentrations of acetaminophen (paracetamol) and codeine were determined in a cross-over study in twelve healthy volunteers after oral and rectal application of a compound preparation. The relative bioavailability from the two forms of application was also computed. The two active substances showed almost parallel plasma concentration paths, and thus were systemically available at the same time. The maximum levels in plasma were already reached after one to two hours. In both active substances the suppositories displayed a classical retardation effect. In contrast to acetaminophen the rectal absorption of codeine was almost as effective as the oral absorption. Thus this application form shows almost bioequivalency vis-à-vis the capsule form. Based on these results the rectal form of administration of codeine as well as the combination of this substance with acetaminophen can be regarded, from the pharmacokinetic point of view, as a rational enhancement of the treatment of various forms of pain.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

6706275

Citation

Kummer, M, and N Mehlhaus. "[Bioavailability of Codeine and Paracetamol in a Combination Preparation Following Oral and Rectal Administration]." Fortschritte Der Medizin, vol. 102, no. 7, 1984, pp. 173-8.
Kummer M, Mehlhaus N. [Bioavailability of codeine and paracetamol in a combination preparation following oral and rectal administration]. Fortschr Med. 1984;102(7):173-8.
Kummer, M., & Mehlhaus, N. (1984). [Bioavailability of codeine and paracetamol in a combination preparation following oral and rectal administration]. Fortschritte Der Medizin, 102(7), 173-8.
Kummer M, Mehlhaus N. [Bioavailability of Codeine and Paracetamol in a Combination Preparation Following Oral and Rectal Administration]. Fortschr Med. 1984 Feb 16;102(7):173-8. PubMed PMID: 6706275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bioavailability of codeine and paracetamol in a combination preparation following oral and rectal administration]. AU - Kummer,M, AU - Mehlhaus,N, PY - 1984/2/16/pubmed PY - 1984/2/16/medline PY - 1984/2/16/entrez SP - 173 EP - 8 JF - Fortschritte der Medizin JO - Fortschr Med VL - 102 IS - 7 N2 - The plasma concentrations of acetaminophen (paracetamol) and codeine were determined in a cross-over study in twelve healthy volunteers after oral and rectal application of a compound preparation. The relative bioavailability from the two forms of application was also computed. The two active substances showed almost parallel plasma concentration paths, and thus were systemically available at the same time. The maximum levels in plasma were already reached after one to two hours. In both active substances the suppositories displayed a classical retardation effect. In contrast to acetaminophen the rectal absorption of codeine was almost as effective as the oral absorption. Thus this application form shows almost bioequivalency vis-à-vis the capsule form. Based on these results the rectal form of administration of codeine as well as the combination of this substance with acetaminophen can be regarded, from the pharmacokinetic point of view, as a rational enhancement of the treatment of various forms of pain. SN - 0015-8178 UR - https://www.unboundmedicine.com/medline/citation/6706275/[Bioavailability_of_codeine_and_paracetamol_in_a_combination_preparation_following_oral_and_rectal_administration]_ DB - PRIME DP - Unbound Medicine ER -