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Bromocriptine therapy for hyperthyroidism due to increased thyrotropin secretion.
J Clin Endocrinol Metab. 1984 May; 58(5):934-6.JC

Abstract

We describe a patient with TSH-induced hyperthyroidism successfully treated with bromocriptine. A 25-yr-old woman was found to have hyperthyroidism due to excessive TSH secretion; no pituitary tumor was found. Her serum T4 level ranged between 21.9 and 25.9 micrograms/dl and that of T3 between 283 and 314 ng/dl. Serum TSH was between 5 and 9 microU/ml with an exaggerated response to TRH. Basal metabolic rate was +26 to +38%. Serum PRL was also elevated (79 ng/ml). Administration of bromocriptine for 4 months decreased serum TSH and PRL levels to normal with a concomitant fall in levels of serum T3 and T4. Regression of the clinical manifestations of hyperthyroidism occurred during bromocriptine drug therapy. These results suggest that reduction in hypothalamic dopaminergic tone may have contributed to the inappropriately increased TSH secretion in the patient.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6707194

Citation

Takamatsu, J, et al. "Bromocriptine Therapy for Hyperthyroidism Due to Increased Thyrotropin Secretion." The Journal of Clinical Endocrinology and Metabolism, vol. 58, no. 5, 1984, pp. 934-6.
Takamatsu J, Mozai T, Kuma K. Bromocriptine therapy for hyperthyroidism due to increased thyrotropin secretion. J Clin Endocrinol Metab. 1984;58(5):934-6.
Takamatsu, J., Mozai, T., & Kuma, K. (1984). Bromocriptine therapy for hyperthyroidism due to increased thyrotropin secretion. The Journal of Clinical Endocrinology and Metabolism, 58(5), 934-6.
Takamatsu J, Mozai T, Kuma K. Bromocriptine Therapy for Hyperthyroidism Due to Increased Thyrotropin Secretion. J Clin Endocrinol Metab. 1984;58(5):934-6. PubMed PMID: 6707194.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bromocriptine therapy for hyperthyroidism due to increased thyrotropin secretion. AU - Takamatsu,J, AU - Mozai,T, AU - Kuma,K, PY - 1984/5/1/pubmed PY - 1984/5/1/medline PY - 1984/5/1/entrez SP - 934 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 58 IS - 5 N2 - We describe a patient with TSH-induced hyperthyroidism successfully treated with bromocriptine. A 25-yr-old woman was found to have hyperthyroidism due to excessive TSH secretion; no pituitary tumor was found. Her serum T4 level ranged between 21.9 and 25.9 micrograms/dl and that of T3 between 283 and 314 ng/dl. Serum TSH was between 5 and 9 microU/ml with an exaggerated response to TRH. Basal metabolic rate was +26 to +38%. Serum PRL was also elevated (79 ng/ml). Administration of bromocriptine for 4 months decreased serum TSH and PRL levels to normal with a concomitant fall in levels of serum T3 and T4. Regression of the clinical manifestations of hyperthyroidism occurred during bromocriptine drug therapy. These results suggest that reduction in hypothalamic dopaminergic tone may have contributed to the inappropriately increased TSH secretion in the patient. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/6707194/Bromocriptine_therapy_for_hyperthyroidism_due_to_increased_thyrotropin_secretion_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-58-5-934 DB - PRIME DP - Unbound Medicine ER -