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The effect of erythromycin on the disposition kinetics of warfarin.
Pharmacology. 1984; 28(3):171-6.P

Abstract

Erythromycin is generally regarded as innocuous in regard to adverse interactions with other drugs. Recently, however, its potentiation of theophylline and warfarin has been reported. The present investigation defined more specifically the kinetics of the interaction between erythromycin and warfarin. Warfarin kinetics were evaluated in 12 normal subjects who took a single 1 mg/kg dose of warfarin with and without erythromycin. Erythromycin (250 mg p.o.) every 6 h for 8 days decreased warfarin clearance by 14% (p less than 0.001). Warfarin's apparent volume of distribution was not affected. Further, the effect of erythromycin was greatest among subjects whose control phase warfarin clearance was relatively slow, and least among those whose control phase warfarin clearance was relatively fast. The magnitude of the decrease in warfarin clearance correlated negatively with control warfarin clearance (r = -0.89, p less than 0.005). These data are consistent with the interpretation that erythromycin can potentiate warfarin-induced hypoprothrombinemia by slowing warfarin clearance.

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Publisher Full Text

Authors

Bachmann K
No affiliation info available
Schwartz JI
No affiliation info available
Forney R
No affiliation info available
Frogameni A
No affiliation info available
Jauregui LE
No affiliation info available

MeSH

AdultDrug InteractionsErythromycinHumansKineticsMaleMetabolic Clearance RateWarfarin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6718483

Citation

Bachmann, K, et al. "The Effect of Erythromycin On the Disposition Kinetics of Warfarin." Pharmacology, vol. 28, no. 3, 1984, pp. 171-6.
Bachmann K, Schwartz JI, Forney R, et al. The effect of erythromycin on the disposition kinetics of warfarin. Pharmacology. 1984;28(3):171-6.
Bachmann, K., Schwartz, J. I., Forney, R., Frogameni, A., & Jauregui, L. E. (1984). The effect of erythromycin on the disposition kinetics of warfarin. Pharmacology, 28(3), 171-6.
Bachmann K, et al. The Effect of Erythromycin On the Disposition Kinetics of Warfarin. Pharmacology. 1984;28(3):171-6. PubMed PMID: 6718483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of erythromycin on the disposition kinetics of warfarin. AU - Bachmann,K, AU - Schwartz,J I, AU - Forney,R,Jr AU - Frogameni,A, AU - Jauregui,L E, PY - 1984/1/1/pubmed PY - 2001/3/28/medline PY - 1984/1/1/entrez SP - 171 EP - 6 JF - Pharmacology JO - Pharmacology VL - 28 IS - 3 N2 - Erythromycin is generally regarded as innocuous in regard to adverse interactions with other drugs. Recently, however, its potentiation of theophylline and warfarin has been reported. The present investigation defined more specifically the kinetics of the interaction between erythromycin and warfarin. Warfarin kinetics were evaluated in 12 normal subjects who took a single 1 mg/kg dose of warfarin with and without erythromycin. Erythromycin (250 mg p.o.) every 6 h for 8 days decreased warfarin clearance by 14% (p less than 0.001). Warfarin's apparent volume of distribution was not affected. Further, the effect of erythromycin was greatest among subjects whose control phase warfarin clearance was relatively slow, and least among those whose control phase warfarin clearance was relatively fast. The magnitude of the decrease in warfarin clearance correlated negatively with control warfarin clearance (r = -0.89, p less than 0.005). These data are consistent with the interpretation that erythromycin can potentiate warfarin-induced hypoprothrombinemia by slowing warfarin clearance. SN - 0031-7012 UR - https://www.unboundmedicine.com/medline/citation/6718483/full_citation L2 - https://www.karger.com?DOI=10.1159/000137958 DB - PRIME DP - Unbound Medicine ER -