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Diagnosis of anemia and iron deficiency: analytic and biological variations of laboratory tests.
Am J Clin Nutr. 1984 Jun; 39(6):937-41.AJ

Abstract

We describe the magnitude of analytic errors and the within-subject biological variations for laboratory tests that are used in the diagnosis of anemia and iron deficiency. For Hb, hematocrit, and red cell indices, coefficients of variation for analytic and biological variations are less than 4%. In general, higher coefficients of variation are characteristic of serum iron, iron-binding capacity, serum ferritin, and erythrocyte protoporphyrin. Particularly high analytic variations between different laboratories have been described for iron-binding capacity and the greatest biological variations have been noted for serum iron. An awareness of these sources of error is helpful in designing studies and in interpreting laboratory results.

Authors

No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6720622

Citation

Dallman, P R.. "Diagnosis of Anemia and Iron Deficiency: Analytic and Biological Variations of Laboratory Tests." The American Journal of Clinical Nutrition, vol. 39, no. 6, 1984, pp. 937-41.
Dallman PR. Diagnosis of anemia and iron deficiency: analytic and biological variations of laboratory tests. Am J Clin Nutr. 1984;39(6):937-41.
Dallman, P. R. (1984). Diagnosis of anemia and iron deficiency: analytic and biological variations of laboratory tests. The American Journal of Clinical Nutrition, 39(6), 937-41.
Dallman PR. Diagnosis of Anemia and Iron Deficiency: Analytic and Biological Variations of Laboratory Tests. Am J Clin Nutr. 1984;39(6):937-41. PubMed PMID: 6720622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diagnosis of anemia and iron deficiency: analytic and biological variations of laboratory tests. A1 - Dallman,P R, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 937 EP - 41 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 39 IS - 6 N2 - We describe the magnitude of analytic errors and the within-subject biological variations for laboratory tests that are used in the diagnosis of anemia and iron deficiency. For Hb, hematocrit, and red cell indices, coefficients of variation for analytic and biological variations are less than 4%. In general, higher coefficients of variation are characteristic of serum iron, iron-binding capacity, serum ferritin, and erythrocyte protoporphyrin. Particularly high analytic variations between different laboratories have been described for iron-binding capacity and the greatest biological variations have been noted for serum iron. An awareness of these sources of error is helpful in designing studies and in interpreting laboratory results. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/6720622/Diagnosis_of_anemia_and_iron_deficiency:_analytic_and_biological_variations_of_laboratory_tests_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/39.6.937 DB - PRIME DP - Unbound Medicine ER -