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Histopathology of gastric carcinoids: a survey of 42 cases.
Histopathology. 1984 Mar; 8(2):183-93.H

Abstract

An unselected series of 42 gastric carcinoids has been reviewed. Clinically the tumours simulated common gastric lesions including ulcer, polyp and carcinoma. No endocrine symptoms were identified. The tumours were most frequent in the body of the stomach and in 25% in that site were multiple. Morphologically most tumours when classified according to Soga (1974) demonstrated a mixed growth pattern. Six tumours displayed an atypical morphology (type D): they were larger and metastasized more frequently than the rest of the tumours. Six tumours contained a few scattered argentaffinic cells but the others were negative indicating negligible serotonin secretion in only a few cases. The Grimelius argyrophilic reaction was positive in most cells in all tested tumours except in three, two of which showed atypical morphology (type D). It is suggested that gastric carcinoids with a type D morphology or a minority cell population of argyrophil cells are dedifferentiated carcinoids which are biologically nearer to gastric carcinomas. The most frequent clinicopathological correlation was achlorhydria linking pernicious anaemia and gastric carcinoids. This indicates pathogenetic similarities between gastric carcinoids and gastric carcinomas.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6724533

Citation

Wilander, E, et al. "Histopathology of Gastric Carcinoids: a Survey of 42 Cases." Histopathology, vol. 8, no. 2, 1984, pp. 183-93.
Wilander E, El-Salhy M, Pitkänen P. Histopathology of gastric carcinoids: a survey of 42 cases. Histopathology. 1984;8(2):183-93.
Wilander, E., El-Salhy, M., & Pitkänen, P. (1984). Histopathology of gastric carcinoids: a survey of 42 cases. Histopathology, 8(2), 183-93.
Wilander E, El-Salhy M, Pitkänen P. Histopathology of Gastric Carcinoids: a Survey of 42 Cases. Histopathology. 1984;8(2):183-93. PubMed PMID: 6724533.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histopathology of gastric carcinoids: a survey of 42 cases. AU - Wilander,E, AU - El-Salhy,M, AU - Pitkänen,P, PY - 1984/3/1/pubmed PY - 1984/3/1/medline PY - 1984/3/1/entrez SP - 183 EP - 93 JF - Histopathology JO - Histopathology VL - 8 IS - 2 N2 - An unselected series of 42 gastric carcinoids has been reviewed. Clinically the tumours simulated common gastric lesions including ulcer, polyp and carcinoma. No endocrine symptoms were identified. The tumours were most frequent in the body of the stomach and in 25% in that site were multiple. Morphologically most tumours when classified according to Soga (1974) demonstrated a mixed growth pattern. Six tumours displayed an atypical morphology (type D): they were larger and metastasized more frequently than the rest of the tumours. Six tumours contained a few scattered argentaffinic cells but the others were negative indicating negligible serotonin secretion in only a few cases. The Grimelius argyrophilic reaction was positive in most cells in all tested tumours except in three, two of which showed atypical morphology (type D). It is suggested that gastric carcinoids with a type D morphology or a minority cell population of argyrophil cells are dedifferentiated carcinoids which are biologically nearer to gastric carcinomas. The most frequent clinicopathological correlation was achlorhydria linking pernicious anaemia and gastric carcinoids. This indicates pathogenetic similarities between gastric carcinoids and gastric carcinomas. SN - 0309-0167 UR - https://www.unboundmedicine.com/medline/citation/6724533/Histopathology_of_gastric_carcinoids:_a_survey_of_42_cases_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0309-0167&date=1984&volume=8&issue=2&spage=183 DB - PRIME DP - Unbound Medicine ER -