Tags

Type your tag names separated by a space and hit enter

Further investigation of the discriminative stimulus properties of MDA.
Pharmacol Biochem Behav. 1984 Apr; 20(4):501-5.PB

Abstract

Rats trained to discriminate either (+)-amphetamine or (+/-)-MDA from saline in a two-lever drug discrimination task, were used to study the stimulus effects of MDA and its two optical isomers. Amphetamine-stimulus generalization occurred to S(+)-MDA, but not to its enantiomer R(-)-MDA. This, coupled with our earlier finding of DOM-stimulus generalization to R(-)-MDA but not to S(+)-MDA, suggests that the stimulus effects of S(+)-MDA are predominantly amphetamine-like while those of R(-)-MDA are more DOM-like. Thus, animals trained to discriminate racemic MDA from saline can apparently recognize members of both classes of agents.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6728867

Citation

Glennon, R A., and R Young. "Further Investigation of the Discriminative Stimulus Properties of MDA." Pharmacology, Biochemistry, and Behavior, vol. 20, no. 4, 1984, pp. 501-5.
Glennon RA, Young R. Further investigation of the discriminative stimulus properties of MDA. Pharmacol Biochem Behav. 1984;20(4):501-5.
Glennon, R. A., & Young, R. (1984). Further investigation of the discriminative stimulus properties of MDA. Pharmacology, Biochemistry, and Behavior, 20(4), 501-5.
Glennon RA, Young R. Further Investigation of the Discriminative Stimulus Properties of MDA. Pharmacol Biochem Behav. 1984;20(4):501-5. PubMed PMID: 6728867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further investigation of the discriminative stimulus properties of MDA. AU - Glennon,R A, AU - Young,R, PY - 1984/4/1/pubmed PY - 1984/4/1/medline PY - 1984/4/1/entrez SP - 501 EP - 5 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 20 IS - 4 N2 - Rats trained to discriminate either (+)-amphetamine or (+/-)-MDA from saline in a two-lever drug discrimination task, were used to study the stimulus effects of MDA and its two optical isomers. Amphetamine-stimulus generalization occurred to S(+)-MDA, but not to its enantiomer R(-)-MDA. This, coupled with our earlier finding of DOM-stimulus generalization to R(-)-MDA but not to S(+)-MDA, suggests that the stimulus effects of S(+)-MDA are predominantly amphetamine-like while those of R(-)-MDA are more DOM-like. Thus, animals trained to discriminate racemic MDA from saline can apparently recognize members of both classes of agents. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/6728867/Further_investigation_of_the_discriminative_stimulus_properties_of_MDA_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0091-3057(84)90295-8 DB - PRIME DP - Unbound Medicine ER -