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Kinetics and thermolability of platelet monoamine oxidase in cluster headache and migraine.
Cephalalgia. 1984 Jun; 4(2):125-34.C

Abstract

Platelet monoamine oxidase activity (MAO) from 33 cluster headache patients (17 males, 16 females) and 34 migraine patients (16 males, 18 females) was assayed. The kinetic constants (apparent Vmax and apparent Km) and the thermolability, measured as the ratio of the platelet MAO activity after and before heat treatment (+52 degrees C, 30 min), were determined. The MAO activity and Vmax values were significantly lower in cluster headache than in migraine and in both headache disorders compared to a control group (62 males, 66 females). When comparing all groups, Km was not significantly different except for migraine females, who had lower Km values compared to control females. Thermolability was significantly higher in cluster headache than in migraine and in both headache disorders compared to the control group. Smokers of five cigarettes or more per day had significantly lower Vmax values but similar Km and thermolability values compared to those smoking less or nothing. The findings of low maximal velocities and high thermolability of platelet MAO in cluster headache and migraine are suggested to represent constitutionally different enzyme properties.

Authors

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Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6733780

Citation

Waldenlind, E, et al. "Kinetics and Thermolability of Platelet Monoamine Oxidase in Cluster Headache and Migraine." Cephalalgia : an International Journal of Headache, vol. 4, no. 2, 1984, pp. 125-34.
Waldenlind E, Sääf J, Ekbom K, et al. Kinetics and thermolability of platelet monoamine oxidase in cluster headache and migraine. Cephalalgia. 1984;4(2):125-34.
Waldenlind, E., Sääf, J., Ekbom, K., Ross, S., Wahlund, L. O., & Wetterberg, L. (1984). Kinetics and thermolability of platelet monoamine oxidase in cluster headache and migraine. Cephalalgia : an International Journal of Headache, 4(2), 125-34.
Waldenlind E, et al. Kinetics and Thermolability of Platelet Monoamine Oxidase in Cluster Headache and Migraine. Cephalalgia. 1984;4(2):125-34. PubMed PMID: 6733780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetics and thermolability of platelet monoamine oxidase in cluster headache and migraine. AU - Waldenlind,E, AU - Sääf,J, AU - Ekbom,K, AU - Ross,S, AU - Wahlund,L O, AU - Wetterberg,L, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 125 EP - 34 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 4 IS - 2 N2 - Platelet monoamine oxidase activity (MAO) from 33 cluster headache patients (17 males, 16 females) and 34 migraine patients (16 males, 18 females) was assayed. The kinetic constants (apparent Vmax and apparent Km) and the thermolability, measured as the ratio of the platelet MAO activity after and before heat treatment (+52 degrees C, 30 min), were determined. The MAO activity and Vmax values were significantly lower in cluster headache than in migraine and in both headache disorders compared to a control group (62 males, 66 females). When comparing all groups, Km was not significantly different except for migraine females, who had lower Km values compared to control females. Thermolability was significantly higher in cluster headache than in migraine and in both headache disorders compared to the control group. Smokers of five cigarettes or more per day had significantly lower Vmax values but similar Km and thermolability values compared to those smoking less or nothing. The findings of low maximal velocities and high thermolability of platelet MAO in cluster headache and migraine are suggested to represent constitutionally different enzyme properties. SN - 0333-1024 UR - https://www.unboundmedicine.com/medline/citation/6733780/Kinetics_and_thermolability_of_platelet_monoamine_oxidase_in_cluster_headache_and_migraine_ L2 - https://journals.sagepub.com/doi/10.1046/j.1468-2982.1984.0402125.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -