Tags

Type your tag names separated by a space and hit enter

Decreased prostaglandin E turnover in infants with essential fatty acid deficiency.
Pediatr Res. 1978 Jun; 12(6):711-4.PR

Abstract

Sick low birth weight infants (LBWI) are prone to develop rapid onset of essential fatty acid (EFA) deficiency. EFAs serve as precursors for prostaglandins (PGs). We measured the excretion of the major urinary metabolite of prostaglandins E1 and E2, 7alpha-hydroxy-5,11-diketotetranorprostane-1,16-dionic acid (PGE-M), in three EFA-deficient and in nine thriving neonates. There was no significant difference in PGE-M excretion between the sexes among thriving infants nor did PGE-M excretion appear to be affected by postconceptual age. However, a significant difference between the PGE-M excretion in the group of infants with EFA deficiency before and after treatment is apparent (P less than 0.05). Significant differences in PGE-M excretion were also found between the control group and the EFA-deficient infants. The severity of the EFA deficiency correlates directly with the degree of PGs excretion. The biochemical evidences of EFA deficiency and the decreased levels of PGE-M excretion are rapidly corrected when patients resume a diet containing EFA.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

673541

Citation

Friedman, Z, et al. "Decreased Prostaglandin E Turnover in Infants With Essential Fatty Acid Deficiency." Pediatric Research, vol. 12, no. 6, 1978, pp. 711-4.
Friedman Z, Seyberth H, Lamberth EL, et al. Decreased prostaglandin E turnover in infants with essential fatty acid deficiency. Pediatr Res. 1978;12(6):711-4.
Friedman, Z., Seyberth, H., Lamberth, E. L., & Oates, J. (1978). Decreased prostaglandin E turnover in infants with essential fatty acid deficiency. Pediatric Research, 12(6), 711-4.
Friedman Z, et al. Decreased Prostaglandin E Turnover in Infants With Essential Fatty Acid Deficiency. Pediatr Res. 1978;12(6):711-4. PubMed PMID: 673541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased prostaglandin E turnover in infants with essential fatty acid deficiency. AU - Friedman,Z, AU - Seyberth,H, AU - Lamberth,E L, AU - Oates,J, PY - 1978/6/1/pubmed PY - 1978/6/1/medline PY - 1978/6/1/entrez SP - 711 EP - 4 JF - Pediatric research JO - Pediatr Res VL - 12 IS - 6 N2 - Sick low birth weight infants (LBWI) are prone to develop rapid onset of essential fatty acid (EFA) deficiency. EFAs serve as precursors for prostaglandins (PGs). We measured the excretion of the major urinary metabolite of prostaglandins E1 and E2, 7alpha-hydroxy-5,11-diketotetranorprostane-1,16-dionic acid (PGE-M), in three EFA-deficient and in nine thriving neonates. There was no significant difference in PGE-M excretion between the sexes among thriving infants nor did PGE-M excretion appear to be affected by postconceptual age. However, a significant difference between the PGE-M excretion in the group of infants with EFA deficiency before and after treatment is apparent (P less than 0.05). Significant differences in PGE-M excretion were also found between the control group and the EFA-deficient infants. The severity of the EFA deficiency correlates directly with the degree of PGs excretion. The biochemical evidences of EFA deficiency and the decreased levels of PGE-M excretion are rapidly corrected when patients resume a diet containing EFA. SN - 0031-3998 UR - https://www.unboundmedicine.com/medline/citation/673541/Decreased_prostaglandin_E_turnover_in_infants_with_essential_fatty_acid_deficiency_ L2 - https://doi.org/10.1203/00006450-197806000-00007 DB - PRIME DP - Unbound Medicine ER -