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Design and analysis of accelerated degradation tests for the stability of biological standards I. Properties of maximum likelihood estimators.
J Biol Stand 1984; 12(2):195-206JB

Abstract

The accelerated degradation test is commonly used to predict the stability of a biological standard during long-term storage at low temperatures. The analysis of complicated by the fact that the standard generally defines its own unit of activity, so only relative rates of degradation at different temperatures can be observed. A series of Monte Carlo simulation studies is described which has been carried out to investigate the accuracy and precision of estimates based on the statistical method and are of use in assessing the extent to which the size and design of the accelerated degradation test influence the precision of the estimate of the low temperature degradation rate.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6736049

Citation

Tydeman, M S., and T B. Kirkwood. "Design and Analysis of Accelerated Degradation Tests for the Stability of Biological Standards I. Properties of Maximum Likelihood Estimators." Journal of Biological Standardization, vol. 12, no. 2, 1984, pp. 195-206.
Tydeman MS, Kirkwood TB. Design and analysis of accelerated degradation tests for the stability of biological standards I. Properties of maximum likelihood estimators. J Biol Stand. 1984;12(2):195-206.
Tydeman, M. S., & Kirkwood, T. B. (1984). Design and analysis of accelerated degradation tests for the stability of biological standards I. Properties of maximum likelihood estimators. Journal of Biological Standardization, 12(2), pp. 195-206.
Tydeman MS, Kirkwood TB. Design and Analysis of Accelerated Degradation Tests for the Stability of Biological Standards I. Properties of Maximum Likelihood Estimators. J Biol Stand. 1984;12(2):195-206. PubMed PMID: 6736049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Design and analysis of accelerated degradation tests for the stability of biological standards I. Properties of maximum likelihood estimators. AU - Tydeman,M S, AU - Kirkwood,T B, PY - 1984/1/1/pubmed PY - 1984/1/1/medline PY - 1984/1/1/entrez SP - 195 EP - 206 JF - Journal of biological standardization JO - J Biol Stand VL - 12 IS - 2 N2 - The accelerated degradation test is commonly used to predict the stability of a biological standard during long-term storage at low temperatures. The analysis of complicated by the fact that the standard generally defines its own unit of activity, so only relative rates of degradation at different temperatures can be observed. A series of Monte Carlo simulation studies is described which has been carried out to investigate the accuracy and precision of estimates based on the statistical method and are of use in assessing the extent to which the size and design of the accelerated degradation test influence the precision of the estimate of the low temperature degradation rate. SN - 0092-1157 UR - https://www.unboundmedicine.com/medline/citation/6736049/Design_and_analysis_of_accelerated_degradation_tests_for_the_stability_of_biological_standards_I__Properties_of_maximum_likelihood_estimators_ DB - PRIME DP - Unbound Medicine ER -