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Studies of the Thymelaeaceae II. Antineoplastic principles of Gnidia kraussiana.
J Nat Prod. 1984 Mar-Apr; 47(2):270-8.JN

Abstract

The acetone and methanol extracts of Gnidia kraussiana roots displayed activity against the P-388 lymphocytic leukemia. Bioactivity-directed fractionation led to the isolation of five daphnane orthoesters , all possessing potent antineoplastic activity. Four of these isolates, gnidilatin (1), gnidilatidin (2), Excoecaria toxin (3), and Pimelea factor P2 (4) have been isolated previously from plants in the Thymelaeaceae and Euphorbiaceae. The fifth compound, kraussianin (5), is a new member of the macrocyclic daphnane orthoester series of compounds.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6736968

Citation

Borris, R P., and G A. Cordell. "Studies of the Thymelaeaceae II. Antineoplastic Principles of Gnidia Kraussiana." Journal of Natural Products, vol. 47, no. 2, 1984, pp. 270-8.
Borris RP, Cordell GA. Studies of the Thymelaeaceae II. Antineoplastic principles of Gnidia kraussiana. J Nat Prod. 1984;47(2):270-8.
Borris, R. P., & Cordell, G. A. (1984). Studies of the Thymelaeaceae II. Antineoplastic principles of Gnidia kraussiana. Journal of Natural Products, 47(2), 270-8.
Borris RP, Cordell GA. Studies of the Thymelaeaceae II. Antineoplastic Principles of Gnidia Kraussiana. J Nat Prod. 1984 Mar-Apr;47(2):270-8. PubMed PMID: 6736968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Studies of the Thymelaeaceae II. Antineoplastic principles of Gnidia kraussiana. AU - Borris,R P, AU - Cordell,G A, PY - 1984/3/1/pubmed PY - 1984/3/1/medline PY - 1984/3/1/entrez SP - 270 EP - 8 JF - Journal of natural products JO - J Nat Prod VL - 47 IS - 2 N2 - The acetone and methanol extracts of Gnidia kraussiana roots displayed activity against the P-388 lymphocytic leukemia. Bioactivity-directed fractionation led to the isolation of five daphnane orthoesters , all possessing potent antineoplastic activity. Four of these isolates, gnidilatin (1), gnidilatidin (2), Excoecaria toxin (3), and Pimelea factor P2 (4) have been isolated previously from plants in the Thymelaeaceae and Euphorbiaceae. The fifth compound, kraussianin (5), is a new member of the macrocyclic daphnane orthoester series of compounds. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/6736968/Studies_of_the_Thymelaeaceae_II__Antineoplastic_principles_of_Gnidia_kraussiana_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6736968 DB - PRIME DP - Unbound Medicine ER -