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Risk factors for pathologically confirmed benign breast disease.
Am J Epidemiol 1984; 120(1):115-22AJ

Abstract

Between November 1981 and March 1983, data were collected to evaluate risk factors for benign breast lesions in a case-control study based on 288 women with histologically proven benign breast disease, admitted for biopsy to the Tumor Institute of Milan, and 285 age-matched controls. Questions were asked about menstrual and reproductive characteristics, marital status, education, history of various diseases, and lifetime use of oral contraceptives and other hormonal treatments. Nulliparity or low parity, late age at first birth, and late menopause were associated with an increased risk of benign breast disease. The elevated risk associated with late age at first birth was not accounted for by parity. Early age at menarche was associated with an increased risk, but the estimate was not statistically significant. The data do not suggest that the use of oral contraceptives or other female hormones (such as estrogen replacement therapy) is related to the risk of benign breast disease. Risk was apparently lower, however, among current and long-term oral contraceptive users. There was no evidence of a trend with reference to body mass index. The present data indicate a substantial agreement between the risk factors for (pathologically confirmed) benign and malignant breast disease, not only directly, by showing a relationship with parity, age at first birth, and age at menopause, but also indirectly, by failing to produce evidence that greater weight or the use of oral contraceptives has a protective effect.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

6741913

Citation

Parazzini, F, et al. "Risk Factors for Pathologically Confirmed Benign Breast Disease." American Journal of Epidemiology, vol. 120, no. 1, 1984, pp. 115-22.
Parazzini F, La Vecchia C, Franceschi S, et al. Risk factors for pathologically confirmed benign breast disease. Am J Epidemiol. 1984;120(1):115-22.
Parazzini, F., La Vecchia, C., Franceschi, S., Decarli, A., Gallus, G., Regallo, M., ... Tognoni, G. (1984). Risk factors for pathologically confirmed benign breast disease. American Journal of Epidemiology, 120(1), pp. 115-22.
Parazzini F, et al. Risk Factors for Pathologically Confirmed Benign Breast Disease. Am J Epidemiol. 1984;120(1):115-22. PubMed PMID: 6741913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for pathologically confirmed benign breast disease. AU - Parazzini,F, AU - La Vecchia,C, AU - Franceschi,S, AU - Decarli,A, AU - Gallus,G, AU - Regallo,M, AU - Liberati,A, AU - Tognoni,G, PY - 1984/7/1/pubmed PY - 1984/7/1/medline PY - 1984/7/1/entrez KW - Age Distribution KW - Age Factors KW - Anatomy KW - Anthropometry KW - Biology KW - Contraception KW - Contraceptive Agents, Female KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Educational Status KW - Estrogens KW - Europe KW - Histology KW - Hormones KW - Italy KW - Mammary Gland Effects KW - Marital Status KW - Maternal Age KW - Mediterranean Countries KW - Menarche KW - Menopause KW - Menstruation KW - Oral Contraceptives KW - Parity KW - Physiology KW - Population KW - Population At Risk KW - Population Characteristics KW - Population Dynamics KW - Reproduction KW - Reproductive Control Agents KW - Research Methodology KW - Southern Europe SP - 115 EP - 22 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 120 IS - 1 N2 - Between November 1981 and March 1983, data were collected to evaluate risk factors for benign breast lesions in a case-control study based on 288 women with histologically proven benign breast disease, admitted for biopsy to the Tumor Institute of Milan, and 285 age-matched controls. Questions were asked about menstrual and reproductive characteristics, marital status, education, history of various diseases, and lifetime use of oral contraceptives and other hormonal treatments. Nulliparity or low parity, late age at first birth, and late menopause were associated with an increased risk of benign breast disease. The elevated risk associated with late age at first birth was not accounted for by parity. Early age at menarche was associated with an increased risk, but the estimate was not statistically significant. The data do not suggest that the use of oral contraceptives or other female hormones (such as estrogen replacement therapy) is related to the risk of benign breast disease. Risk was apparently lower, however, among current and long-term oral contraceptive users. There was no evidence of a trend with reference to body mass index. The present data indicate a substantial agreement between the risk factors for (pathologically confirmed) benign and malignant breast disease, not only directly, by showing a relationship with parity, age at first birth, and age at menopause, but also indirectly, by failing to produce evidence that greater weight or the use of oral contraceptives has a protective effect. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/6741913/Risk_factors_for_pathologically_confirmed_benign_breast_disease_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/oxfordjournals.aje.a113860 DB - PRIME DP - Unbound Medicine ER -