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Oral contraceptives and benign breast disease: a case-control study.

Abstract

The relationship between benign breast disease and use of oral contraceptives was analyzed in a case-control study conducted in Milan with 288 cases of clinically relevant and histologically confirmed benign breast disease and 285 age-matched controls with a spectrum of acute conditions apparently unrelated to use of oral contraceptives. Compared to the risk for women who had never used oral contraceptives, the relative risk for users was 1.0 (95% confidence interval: 0.6 to 1.5). There was no significant association with duration of use; however, a significantly lower relative risk was found in women using oral contraceptives during the year before breast biopsy (relative risk: 0.4; 95% confidence interval: 0.2 to 0.8). The protection in current users increased with increasing duration of use. In spite of this finding, the overall results of the present study do not support the hypothesis that oral contraceptive use protects against development of histologically confirmed and clinically relevant benign breast disease.

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  • Authors

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    Source

    MeSH

    Adolescent
    Adult
    Breast Neoplasms
    Contraceptives, Oral
    Female
    Fibrocystic Breast Disease
    Humans
    Middle Aged
    Risk
    Surveys and Questionnaires
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    6742041

    Citation

    Franceschi, S, et al. "Oral Contraceptives and Benign Breast Disease: a Case-control Study." American Journal of Obstetrics and Gynecology, vol. 149, no. 6, 1984, pp. 602-6.
    Franceschi S, La Vecchia C, Parazzini F, et al. Oral contraceptives and benign breast disease: a case-control study. Am J Obstet Gynecol. 1984;149(6):602-6.
    Franceschi, S., La Vecchia, C., Parazzini, F., Fasoli, M., Regallo, M., Decarli, A., ... Tognoni, G. (1984). Oral contraceptives and benign breast disease: a case-control study. American Journal of Obstetrics and Gynecology, 149(6), pp. 602-6.
    Franceschi S, et al. Oral Contraceptives and Benign Breast Disease: a Case-control Study. Am J Obstet Gynecol. 1984 Jul 15;149(6):602-6. PubMed PMID: 6742041.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Oral contraceptives and benign breast disease: a case-control study. AU - Franceschi,S, AU - La Vecchia,C, AU - Parazzini,F, AU - Fasoli,M, AU - Regallo,M, AU - Decarli,A, AU - Gallus,G, AU - Tognoni,G, PY - 1984/7/15/pubmed PY - 1984/7/15/medline PY - 1984/7/15/entrez KW - Biology KW - Contraception KW - Contraception Continuation KW - Contraceptive Agents KW - Contraceptive Agents, Female KW - Contraceptive Methods--beneficial effects KW - Data Collection KW - Developed Countries KW - Diseases KW - Europe KW - Family Planning KW - Italy KW - Mammary Gland Effects KW - Mediterranean Countries KW - Oral Contraceptives--beneficial effects KW - Physiology KW - Population At Risk KW - Research Methodology KW - Southern Europe SP - 602 EP - 6 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 149 IS - 6 N2 - The relationship between benign breast disease and use of oral contraceptives was analyzed in a case-control study conducted in Milan with 288 cases of clinically relevant and histologically confirmed benign breast disease and 285 age-matched controls with a spectrum of acute conditions apparently unrelated to use of oral contraceptives. Compared to the risk for women who had never used oral contraceptives, the relative risk for users was 1.0 (95% confidence interval: 0.6 to 1.5). There was no significant association with duration of use; however, a significantly lower relative risk was found in women using oral contraceptives during the year before breast biopsy (relative risk: 0.4; 95% confidence interval: 0.2 to 0.8). The protection in current users increased with increasing duration of use. In spite of this finding, the overall results of the present study do not support the hypothesis that oral contraceptive use protects against development of histologically confirmed and clinically relevant benign breast disease. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/6742041/Oral_contraceptives_and_benign_breast_disease:_a_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(84)90242-4 DB - PRIME DP - Unbound Medicine ER -