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An objective sign in painful crisis in sickle cell anemia: the concomitant reduction of high density red cells.

Abstract

The etiopathologic basis of painful crisis in sickle cell anemia is largely unknown, and no objective criteria for its diagnosis and follow-up exist at present. We have studied 11 patients through 14 painful crises and observed a significant decrease of the densest fraction of red cells in 12 of the 14 crises as determined by isopycnic Percoll-Stractan continuous density gradients. If the first observation is normalized to 100%, the average decrease in dense cells was 77% with a range of 36% to 94%. The time needed for the percentage of dense cells to return to the steady-state level varied from seven to more than 30 days. These findings were in sharp contrast to the stability of the density pattern observed in another group of sickle cell patients, who were studied during crisis-free periods. The mechanism of the disappearance of dense cells could involve selective destruction by the reticuloendothelial (RE) system, selective sequestration in the areas of vasoocclusion, or a combination of both factors.

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  • Authors

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    Source

    Blood 64:2 1984 Aug pg 559-63

    MeSH

    Adult
    Anemia, Sickle Cell
    Cell Separation
    Centrifugation, Density Gradient
    Erythrocyte Count
    Erythrocytes, Abnormal
    Female
    Humans
    Male
    Pain
    Time Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    6743830

    Citation

    Fabry, M E., et al. "An Objective Sign in Painful Crisis in Sickle Cell Anemia: the Concomitant Reduction of High Density Red Cells." Blood, vol. 64, no. 2, 1984, pp. 559-63.
    Fabry ME, Benjamin L, Lawrence C, et al. An objective sign in painful crisis in sickle cell anemia: the concomitant reduction of high density red cells. Blood. 1984;64(2):559-63.
    Fabry, M. E., Benjamin, L., Lawrence, C., & Nagel, R. L. (1984). An objective sign in painful crisis in sickle cell anemia: the concomitant reduction of high density red cells. Blood, 64(2), pp. 559-63.
    Fabry ME, et al. An Objective Sign in Painful Crisis in Sickle Cell Anemia: the Concomitant Reduction of High Density Red Cells. Blood. 1984;64(2):559-63. PubMed PMID: 6743830.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - An objective sign in painful crisis in sickle cell anemia: the concomitant reduction of high density red cells. AU - Fabry,M E, AU - Benjamin,L, AU - Lawrence,C, AU - Nagel,R L, PY - 1984/8/1/pubmed PY - 1984/8/1/medline PY - 1984/8/1/entrez SP - 559 EP - 63 JF - Blood JO - Blood VL - 64 IS - 2 N2 - The etiopathologic basis of painful crisis in sickle cell anemia is largely unknown, and no objective criteria for its diagnosis and follow-up exist at present. We have studied 11 patients through 14 painful crises and observed a significant decrease of the densest fraction of red cells in 12 of the 14 crises as determined by isopycnic Percoll-Stractan continuous density gradients. If the first observation is normalized to 100%, the average decrease in dense cells was 77% with a range of 36% to 94%. The time needed for the percentage of dense cells to return to the steady-state level varied from seven to more than 30 days. These findings were in sharp contrast to the stability of the density pattern observed in another group of sickle cell patients, who were studied during crisis-free periods. The mechanism of the disappearance of dense cells could involve selective destruction by the reticuloendothelial (RE) system, selective sequestration in the areas of vasoocclusion, or a combination of both factors. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/6743830/An_objective_sign_in_painful_crisis_in_sickle_cell_anemia:_the_concomitant_reduction_of_high_density_red_cells_ L2 - http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=6743830 DB - PRIME DP - Unbound Medicine ER -