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Pharmacodynamics of alcide, a new antimicrobial compound, in rat and rabbit.
Fundam Appl Toxicol. 1984 Jun; 4(3 Pt 1):479-84.FA

Abstract

Alcide is a germicidal preparation which has been shown to kill a wide range of common pathogenic bacteria as well as fungi, in vitro. This preparation is composed of Part A and Part B which contains sodium chlorite (NaClO2) and lactic acid as the active ingredients, respectively. The two parts are combined in equal volumes immediately prior to application resulting in the formation of chlorine dioxide (ClO2). Alcide gel was applied to the shaven backs of 18 female Sprague-Dawley rats in a 2.0-g/kg dose by combining 1 g of each part immediately prior to administration. This dose was applied for a period of 10 days to reach a steady state. On the 11th day, 36Cl-labeled Alcide gel, which contained Na36ClO2 in Part A, was administered to the animals in a 0.6-g dose (2.0 g/kg) containing 0.1 microCi. The half-life for 36Cl absorption was 22.1 hr while the elimination half-life was 64.0 hr. 36Cl was excreted by the kidneys with chloride (Cl-) and chlorite as the metabolites. Ninety-six hours after Alcide administration, radioactivity was highest in whole blood and lowest in fat. In a 90-day subchronic dermal toxicity study in rabbits, exposure to Alcide gel resulted in decreased glutathione concentrations in blood of the group receiving 2.0 g/kg Alcide as well as in the placebo gel group which received the same dose of gel.

Authors

Scatina J
No affiliation info available
Abdel-Rahman MS
No affiliation info available
Gerges SE
No affiliation info available
Khan MY
No affiliation info available
Gona O
No affiliation info available

MeSH

AnimalsChlorineChlorine CompoundsDisinfectantsFemaleGelsIntestinal AbsorptionKineticsMaleOsmotic FragilityOxidesRabbitsRatsRats, Inbred StrainsSkin DiseasesSpecies SpecificityTime FactorsTissue Distribution

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6745537

Citation

Scatina, J, et al. "Pharmacodynamics of Alcide, a New Antimicrobial Compound, in Rat and Rabbit." Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology, vol. 4, no. 3 Pt 1, 1984, pp. 479-84.
Scatina J, Abdel-Rahman MS, Gerges SE, et al. Pharmacodynamics of alcide, a new antimicrobial compound, in rat and rabbit. Fundam Appl Toxicol. 1984;4(3 Pt 1):479-84.
Scatina, J., Abdel-Rahman, M. S., Gerges, S. E., Khan, M. Y., & Gona, O. (1984). Pharmacodynamics of alcide, a new antimicrobial compound, in rat and rabbit. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology, 4(3 Pt 1), 479-84.
Scatina J, et al. Pharmacodynamics of Alcide, a New Antimicrobial Compound, in Rat and Rabbit. Fundam Appl Toxicol. 1984;4(3 Pt 1):479-84. PubMed PMID: 6745537.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacodynamics of alcide, a new antimicrobial compound, in rat and rabbit. AU - Scatina,J, AU - Abdel-Rahman,M S, AU - Gerges,S E, AU - Khan,M Y, AU - Gona,O, PY - 1984/6/1/pubmed PY - 1984/6/1/medline PY - 1984/6/1/entrez SP - 479 EP - 84 JF - Fundamental and applied toxicology : official journal of the Society of Toxicology JO - Fundam Appl Toxicol VL - 4 IS - 3 Pt 1 N2 - Alcide is a germicidal preparation which has been shown to kill a wide range of common pathogenic bacteria as well as fungi, in vitro. This preparation is composed of Part A and Part B which contains sodium chlorite (NaClO2) and lactic acid as the active ingredients, respectively. The two parts are combined in equal volumes immediately prior to application resulting in the formation of chlorine dioxide (ClO2). Alcide gel was applied to the shaven backs of 18 female Sprague-Dawley rats in a 2.0-g/kg dose by combining 1 g of each part immediately prior to administration. This dose was applied for a period of 10 days to reach a steady state. On the 11th day, 36Cl-labeled Alcide gel, which contained Na36ClO2 in Part A, was administered to the animals in a 0.6-g dose (2.0 g/kg) containing 0.1 microCi. The half-life for 36Cl absorption was 22.1 hr while the elimination half-life was 64.0 hr. 36Cl was excreted by the kidneys with chloride (Cl-) and chlorite as the metabolites. Ninety-six hours after Alcide administration, radioactivity was highest in whole blood and lowest in fat. In a 90-day subchronic dermal toxicity study in rabbits, exposure to Alcide gel resulted in decreased glutathione concentrations in blood of the group receiving 2.0 g/kg Alcide as well as in the placebo gel group which received the same dose of gel. SN - 0272-0590 UR - https://www.unboundmedicine.com/medline/citation/6745537/Pharmacodynamics_of_alcide_a_new_antimicrobial_compound_in_rat_and_rabbit_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:6745537 DB - PRIME DP - Unbound Medicine ER -