Abstract
5-HT precursors are used in depressions on the basis of the 5-HT hypothesis - an hypothesis which postulates that a cerebral 5-HT deficiency can play a role in the pathogenesis of depressions. This article presents a survey of the results obtained by this therapeutic strategy. There are strong indications that 5-HTP is of therapeutic value, particularly in the 5-HT-deficient subgroup of vital depressions. In the same subgroup, one controlled study has so far also shown a prophylatic 5-HTP effect. The effect of clomipramine is potentiated by 1-5-HTP, and this combination can give good results in therapy-resistant vital depressions. Other tricyclic compounds have not been studied in this context, nor have selective 5-HT reuptake inhibitors. The results of tryptophan studies are less unequivocal, possibly due to pharmacokinetic factors. Another possible explanation might be that, unlike 5-HTP research, tryptophan studies have so far disregarded the patient's serotonergic status. 5-HT research in depressions has also yielded the concept of the biochemical classifiability of depressions. This may become an important supplement to the conventional criteria of classification of depressions: symptomatology, etiology, and course.
TY - JOUR
T1 - Serotonin precursors in the treatment of depression.
A1 - van Praag,H M,
PY - 1982/1/1/pubmed
PY - 1982/1/1/medline
PY - 1982/1/1/entrez
SP - 259
EP - 86
JF - Advances in biochemical psychopharmacology
JO - Adv Biochem Psychopharmacol
VL - 34
N2 - 5-HT precursors are used in depressions on the basis of the 5-HT hypothesis - an hypothesis which postulates that a cerebral 5-HT deficiency can play a role in the pathogenesis of depressions. This article presents a survey of the results obtained by this therapeutic strategy. There are strong indications that 5-HTP is of therapeutic value, particularly in the 5-HT-deficient subgroup of vital depressions. In the same subgroup, one controlled study has so far also shown a prophylatic 5-HTP effect. The effect of clomipramine is potentiated by 1-5-HTP, and this combination can give good results in therapy-resistant vital depressions. Other tricyclic compounds have not been studied in this context, nor have selective 5-HT reuptake inhibitors. The results of tryptophan studies are less unequivocal, possibly due to pharmacokinetic factors. Another possible explanation might be that, unlike 5-HTP research, tryptophan studies have so far disregarded the patient's serotonergic status. 5-HT research in depressions has also yielded the concept of the biochemical classifiability of depressions. This may become an important supplement to the conventional criteria of classification of depressions: symptomatology, etiology, and course.
SN - 0065-2229
UR - https://www.unboundmedicine.com/medline/citation/6753514/Serotonin_precursors_in_the_treatment_of_depression_
L2 - http://www.diseaseinfosearch.org/result/2199
DB - PRIME
DP - Unbound Medicine
ER -