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Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep.
Adv Shock Res. 1982; 7:199-207.AS

Abstract

The relationship between prostacyclin and thromboxane activity in plasma or lymph of endotoxemia sheep was studied to better understand the physiologic significance of these two vasoactive compounds. Conscious sheep received either endotoxin alone or endotoxin plus a five-hour infusion of prostacyclin. Endotoxin alone produced a pulmonary arterial hypertension, a significant decrease in cardiac output, an increase in the lung lymph flow rate, and a leukopenia. Plasma prostacyclin and thromboxane concentrations were elevated to the same extent, while pulmonary lymph thromboxane concentrations were greater than those of prostacyclin. The administration of exogenous prostacyclin significantly attenuated the hemodynamic changes following endotoxin, but not the leukopenia. During the prostacyclin infusion, plasma and lymph prostacyclin concentration were tenfold higher than those seen with endotoxin alone, while thromboxane concentrations were six to eightfold lower. Thus, high circulating prostacyclin concentrations resulted in an inhibition of thromboxane production with an associated attenuation of the hemodynamic response to endotoxin.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6753534

Citation

Flynn, J T., and R H. Demling. "Inhibition of Endogenous Thromboxane Synthesis By Exogenous Prostacyclin During Endotoxemia in Conscious Sheep." Advances in Shock Research, vol. 7, 1982, pp. 199-207.
Flynn JT, Demling RH. Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. Adv Shock Res. 1982;7:199-207.
Flynn, J. T., & Demling, R. H. (1982). Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. Advances in Shock Research, 7, 199-207.
Flynn JT, Demling RH. Inhibition of Endogenous Thromboxane Synthesis By Exogenous Prostacyclin During Endotoxemia in Conscious Sheep. Adv Shock Res. 1982;7:199-207. PubMed PMID: 6753534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of endogenous thromboxane synthesis by exogenous prostacyclin during endotoxemia in conscious sheep. AU - Flynn,J T, AU - Demling,R H, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 199 EP - 207 JF - Advances in shock research JO - Adv Shock Res VL - 7 N2 - The relationship between prostacyclin and thromboxane activity in plasma or lymph of endotoxemia sheep was studied to better understand the physiologic significance of these two vasoactive compounds. Conscious sheep received either endotoxin alone or endotoxin plus a five-hour infusion of prostacyclin. Endotoxin alone produced a pulmonary arterial hypertension, a significant decrease in cardiac output, an increase in the lung lymph flow rate, and a leukopenia. Plasma prostacyclin and thromboxane concentrations were elevated to the same extent, while pulmonary lymph thromboxane concentrations were greater than those of prostacyclin. The administration of exogenous prostacyclin significantly attenuated the hemodynamic changes following endotoxin, but not the leukopenia. During the prostacyclin infusion, plasma and lymph prostacyclin concentration were tenfold higher than those seen with endotoxin alone, while thromboxane concentrations were six to eightfold lower. Thus, high circulating prostacyclin concentrations resulted in an inhibition of thromboxane production with an associated attenuation of the hemodynamic response to endotoxin. SN - 0195-878X UR - https://www.unboundmedicine.com/medline/citation/6753534/Inhibition_of_endogenous_thromboxane_synthesis_by_exogenous_prostacyclin_during_endotoxemia_in_conscious_sheep_ DB - PRIME DP - Unbound Medicine ER -