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The hypotensive effect of a single daily dose of labetalol: a preliminary study.
Int J Clin Pharmacol Ther Toxicol. 1982 Sep; 20(9):438-45.IJ

Abstract

We analyzed the efficacy of a single daily dose of labetalol (300 mg) administered at 9 a.m. in six inpatients suffering from medium-severe hypertension. The study was conducted on 3 consecutive days, during which the patients were on labetalol, placebo, and non-treatment (control) according to a trial design of the Latin square type, balanced for residual effects. The hypotensive effect of labetalol manifests itself between hours 1 and 2 after administration of the drug. The systolic and diastolic blood pressure values always proved lower after labetalol as compared to placebo and non-treatment (control) as well as to the average of the latter two values (placebo + control) divided by 2. No side effects were detected.

Authors

Rossi A
No affiliation info available
Ziacchi V
No affiliation info available
Lomanto B
No affiliation info available

MeSH

AdultAgedBlood PressureClinical Trials as TopicEthanolaminesFemaleHumansHypertensionLabetalolMaleMiddle AgedTime Factors

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

6754634

Citation

Rossi, A, et al. "The Hypotensive Effect of a Single Daily Dose of Labetalol: a Preliminary Study." International Journal of Clinical Pharmacology, Therapy, and Toxicology, vol. 20, no. 9, 1982, pp. 438-45.
Rossi A, Ziacchi V, Lomanto B. The hypotensive effect of a single daily dose of labetalol: a preliminary study. Int J Clin Pharmacol Ther Toxicol. 1982;20(9):438-45.
Rossi, A., Ziacchi, V., & Lomanto, B. (1982). The hypotensive effect of a single daily dose of labetalol: a preliminary study. International Journal of Clinical Pharmacology, Therapy, and Toxicology, 20(9), 438-45.
Rossi A, Ziacchi V, Lomanto B. The Hypotensive Effect of a Single Daily Dose of Labetalol: a Preliminary Study. Int J Clin Pharmacol Ther Toxicol. 1982;20(9):438-45. PubMed PMID: 6754634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The hypotensive effect of a single daily dose of labetalol: a preliminary study. AU - Rossi,A, AU - Ziacchi,V, AU - Lomanto,B, PY - 1982/9/1/pubmed PY - 1982/9/1/medline PY - 1982/9/1/entrez SP - 438 EP - 45 JF - International journal of clinical pharmacology, therapy, and toxicology JO - Int J Clin Pharmacol Ther Toxicol VL - 20 IS - 9 N2 - We analyzed the efficacy of a single daily dose of labetalol (300 mg) administered at 9 a.m. in six inpatients suffering from medium-severe hypertension. The study was conducted on 3 consecutive days, during which the patients were on labetalol, placebo, and non-treatment (control) according to a trial design of the Latin square type, balanced for residual effects. The hypotensive effect of labetalol manifests itself between hours 1 and 2 after administration of the drug. The systolic and diastolic blood pressure values always proved lower after labetalol as compared to placebo and non-treatment (control) as well as to the average of the latter two values (placebo + control) divided by 2. No side effects were detected. SN - 0174-4879 UR - https://www.unboundmedicine.com/medline/citation/6754634/The_hypotensive_effect_of_a_single_daily_dose_of_labetalol:_a_preliminary_study_ DB - PRIME DP - Unbound Medicine ER -