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Effect of metabolic control of the serum lipid and lipoprotein levels on insulin-dependent diabetes mellitus.
Acta Med Acad Sci Hung. 1982; 39(3-4):117-23.AM

Abstract

In diabetic patients with poor metabolic control (Group I) and with repeated hypoglycaemic crises (Group II) the serum concentration of cholesterol, triglyceride, of LDL, VLDL and HDL-cholesterol, as well of VLDL and LDL + HDL-triglyceride were measured before and after metabolic control and before and after control of the hypoglycaemic crises. Parallel with the control of diabetic metabolism in Group I, achieved in 15 +/- 6 days, a significant increase in HDL-cholesterol concentration was demonstrable, together with a decrease in the mean value of blood glucose and of daily urinary glucose excretion. In the diabetic patients of Group I, the LDL-cholesterol, serum triglyceride and VLDL-triglyceride levels were significantly higher, the HDL cholesterol levels significantly lower before as well as after metabolic correction, than in the control group. In Group II the serum lipid and lipoprotein lipid concentrations remained unaffected by the control of the hypoglycaemic crises. The results indicate that lipid metabolism in diabetes may considerably be affected by insulin deficiency, but it will respond to an intensified insulin effect. An increase in the concentration of the antiatherogenic HDL-cholesterol is an essential factor of the improvement.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6764327

Citation

Romics, L, et al. "Effect of Metabolic Control of the Serum Lipid and Lipoprotein Levels On Insulin-dependent Diabetes Mellitus." Acta Medica Academiae Scientiarum Hungaricae, vol. 39, no. 3-4, 1982, pp. 117-23.
Romics L, Karádi I, Rozenberczki M, et al. Effect of metabolic control of the serum lipid and lipoprotein levels on insulin-dependent diabetes mellitus. Acta Med Acad Sci Hung. 1982;39(3-4):117-23.
Romics, L., Karádi, I., Rozenberczki, M., & Kammerer, L. (1982). Effect of metabolic control of the serum lipid and lipoprotein levels on insulin-dependent diabetes mellitus. Acta Medica Academiae Scientiarum Hungaricae, 39(3-4), 117-23.
Romics L, et al. Effect of Metabolic Control of the Serum Lipid and Lipoprotein Levels On Insulin-dependent Diabetes Mellitus. Acta Med Acad Sci Hung. 1982;39(3-4):117-23. PubMed PMID: 6764327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of metabolic control of the serum lipid and lipoprotein levels on insulin-dependent diabetes mellitus. AU - Romics,L, AU - Karádi,I, AU - Rozenberczki,M, AU - Kammerer,L, PY - 1982/1/1/pubmed PY - 1982/1/1/medline PY - 1982/1/1/entrez SP - 117 EP - 23 JF - Acta medica Academiae Scientiarum Hungaricae JO - Acta Med Acad Sci Hung VL - 39 IS - 3-4 N2 - In diabetic patients with poor metabolic control (Group I) and with repeated hypoglycaemic crises (Group II) the serum concentration of cholesterol, triglyceride, of LDL, VLDL and HDL-cholesterol, as well of VLDL and LDL + HDL-triglyceride were measured before and after metabolic control and before and after control of the hypoglycaemic crises. Parallel with the control of diabetic metabolism in Group I, achieved in 15 +/- 6 days, a significant increase in HDL-cholesterol concentration was demonstrable, together with a decrease in the mean value of blood glucose and of daily urinary glucose excretion. In the diabetic patients of Group I, the LDL-cholesterol, serum triglyceride and VLDL-triglyceride levels were significantly higher, the HDL cholesterol levels significantly lower before as well as after metabolic correction, than in the control group. In Group II the serum lipid and lipoprotein lipid concentrations remained unaffected by the control of the hypoglycaemic crises. The results indicate that lipid metabolism in diabetes may considerably be affected by insulin deficiency, but it will respond to an intensified insulin effect. An increase in the concentration of the antiatherogenic HDL-cholesterol is an essential factor of the improvement. SN - 0001-5989 UR - https://www.unboundmedicine.com/medline/citation/6764327/Effect_of_metabolic_control_of_the_serum_lipid_and_lipoprotein_levels_on_insulin_dependent_diabetes_mellitus_ L2 - http://www.diseaseinfosearch.org/result/2236 DB - PRIME DP - Unbound Medicine ER -