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Chronic experimental glaucoma in primates. I. Production of elevated intraocular pressure by anterior chamber injection of autologous ghost red blood cells.
Invest Ophthalmol Vis Sci. 1980 Feb; 19(2):126-36.IO

Abstract

Chronic elevations of intraocular pressure (IOP) were produced in rabbit and monkey eyes by anterior chamber injection of autologous fixed red blood cells. The method confirms the possibility of secondary glaucoma due to trabecular obstruction by ghost cells in eyes with intraocular hemorrhage. In primates, decreased aqueous outflow may result from direct obstruction by free cells and macrophages as well as swelling of trabecular endothelium following phagocytosis of cellular debris. IOP elevations for from 2 days to greater than 1 month were produced in order to study the effects of elevated IOP on ocular tissues. The model has the advantages of producing IOP elevation easily and without associated intraocular inflammation. The extensive filling of the anterior chamber necessary to produce IOP rises in healthy animal eyes leads to the disadvantage of poor visibility of the optic disk. In rabbit eyes, chronic IOP elevation leads to corneal enlargement and ectasia, making IOP measurements difficult.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6766124

Citation

Quigley, H A., and E M. Addicks. "Chronic Experimental Glaucoma in Primates. I. Production of Elevated Intraocular Pressure By Anterior Chamber Injection of Autologous Ghost Red Blood Cells." Investigative Ophthalmology & Visual Science, vol. 19, no. 2, 1980, pp. 126-36.
Quigley HA, Addicks EM. Chronic experimental glaucoma in primates. I. Production of elevated intraocular pressure by anterior chamber injection of autologous ghost red blood cells. Invest Ophthalmol Vis Sci. 1980;19(2):126-36.
Quigley, H. A., & Addicks, E. M. (1980). Chronic experimental glaucoma in primates. I. Production of elevated intraocular pressure by anterior chamber injection of autologous ghost red blood cells. Investigative Ophthalmology & Visual Science, 19(2), 126-36.
Quigley HA, Addicks EM. Chronic Experimental Glaucoma in Primates. I. Production of Elevated Intraocular Pressure By Anterior Chamber Injection of Autologous Ghost Red Blood Cells. Invest Ophthalmol Vis Sci. 1980;19(2):126-36. PubMed PMID: 6766124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic experimental glaucoma in primates. I. Production of elevated intraocular pressure by anterior chamber injection of autologous ghost red blood cells. AU - Quigley,H A, AU - Addicks,E M, PY - 1980/2/1/pubmed PY - 1980/2/1/medline PY - 1980/2/1/entrez SP - 126 EP - 36 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 19 IS - 2 N2 - Chronic elevations of intraocular pressure (IOP) were produced in rabbit and monkey eyes by anterior chamber injection of autologous fixed red blood cells. The method confirms the possibility of secondary glaucoma due to trabecular obstruction by ghost cells in eyes with intraocular hemorrhage. In primates, decreased aqueous outflow may result from direct obstruction by free cells and macrophages as well as swelling of trabecular endothelium following phagocytosis of cellular debris. IOP elevations for from 2 days to greater than 1 month were produced in order to study the effects of elevated IOP on ocular tissues. The model has the advantages of producing IOP elevation easily and without associated intraocular inflammation. The extensive filling of the anterior chamber necessary to produce IOP rises in healthy animal eyes leads to the disadvantage of poor visibility of the optic disk. In rabbit eyes, chronic IOP elevation leads to corneal enlargement and ectasia, making IOP measurements difficult. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/6766124/Chronic_experimental_glaucoma_in_primates__I__Production_of_elevated_intraocular_pressure_by_anterior_chamber_injection_of_autologous_ghost_red_blood_cells_ L2 - https://iovs.arvojournals.org/article.aspx?volume=19&issue=2&page=126 DB - PRIME DP - Unbound Medicine ER -