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[Conservative therapy of arterial occlusive diseases. Double-blind study on the effect of butalamine hydrochloride].
Fortschr Med. 1980 Feb 21; 98(7):257-60.FM

Abstract

In a double blind placebo-controlled trial the influence of butalamine-hydrochloride (Adrevil forte) in a daily dosage of 3 x 2 tablets on the exercise tolerance of muscles with impaired blood flow in the lower limb was evaluated. The drug was tested versus placebo in a total of 32 patients suffering from peripheral arterial insufficiency stadium II according to Fontaine with occlusions in one or both extremities. Clinical parameters measured were muscle ergometry, plethysmography as well as the assessment of the painfree walking distance. During the whole trial the systemic blood pressure was monitored. The group receiving the active drug showed already after two weeks therapy a statistically significant improvement in the walking distance. After the end of 8 weeks therapy the walking distance in the group under active drug therapy was increased 4 times. Measurements of perfusion also showed significantly higher values under active therapy. The systemic blood pressure was not affected during the 8 weeks therapy with Adrevil forte.

Authors

No affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

6767648

Citation

Seboldt, H. "[Conservative Therapy of Arterial Occlusive Diseases. Double-blind Study On the Effect of Butalamine Hydrochloride]." Fortschritte Der Medizin, vol. 98, no. 7, 1980, pp. 257-60.
Seboldt H. [Conservative therapy of arterial occlusive diseases. Double-blind study on the effect of butalamine hydrochloride]. Fortschr Med. 1980;98(7):257-60.
Seboldt, H. (1980). [Conservative therapy of arterial occlusive diseases. Double-blind study on the effect of butalamine hydrochloride]. Fortschritte Der Medizin, 98(7), 257-60.
Seboldt H. [Conservative Therapy of Arterial Occlusive Diseases. Double-blind Study On the Effect of Butalamine Hydrochloride]. Fortschr Med. 1980 Feb 21;98(7):257-60. PubMed PMID: 6767648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Conservative therapy of arterial occlusive diseases. Double-blind study on the effect of butalamine hydrochloride]. A1 - Seboldt,H, PY - 1980/2/21/pubmed PY - 1980/2/21/medline PY - 1980/2/21/entrez SP - 257 EP - 60 JF - Fortschritte der Medizin JO - Fortschr. Med. VL - 98 IS - 7 N2 - In a double blind placebo-controlled trial the influence of butalamine-hydrochloride (Adrevil forte) in a daily dosage of 3 x 2 tablets on the exercise tolerance of muscles with impaired blood flow in the lower limb was evaluated. The drug was tested versus placebo in a total of 32 patients suffering from peripheral arterial insufficiency stadium II according to Fontaine with occlusions in one or both extremities. Clinical parameters measured were muscle ergometry, plethysmography as well as the assessment of the painfree walking distance. During the whole trial the systemic blood pressure was monitored. The group receiving the active drug showed already after two weeks therapy a statistically significant improvement in the walking distance. After the end of 8 weeks therapy the walking distance in the group under active drug therapy was increased 4 times. Measurements of perfusion also showed significantly higher values under active therapy. The systemic blood pressure was not affected during the 8 weeks therapy with Adrevil forte. SN - 0015-8178 UR - https://www.unboundmedicine.com/medline/citation/6767648/[Conservative_therapy_of_arterial_occlusive_diseases__Double_blind_study_on_the_effect_of_butalamine_hydrochloride]_ DB - PRIME DP - Unbound Medicine ER -