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The biologic activity of a potent analogue of gonadotropin-releasing hormone in normal and hypogonadotropic men.
N Engl J Med. 1980 May 08; 302(19):1052-7.NEJM

Abstract

We studied the biologic activity of a long-acting analogue of luteinizing hormone-releasing hormone, D-Trp6-Pro9-NEt-LHRH (LHRHa), in five normal men and four hypogonadotropic men previously unresponsive to natural LHRH. All subjects responded to LHRAa, but there were quantitative and qualitative differences between the normal and hypogonadotropic men. Normal men showed a linear dose-response relation, endogenous gonadal steroid secretion, and an adult pattern of gonadotropin secretion characterized by a high ratio of luteinizing hormone (LH) to follicle-stimulating hormone (FSH). Hypogonadotropic men had improving pituitary responses to each dose of LHRHa (priming response), no demonstrable gonadal steroid secretion, and a prepubertal pattern of gonadotropin release characterized by reversal of the normal ratio of LH to FSH. When compared with native LHRH, LHRHa had an augmented ability to discharge gonadotropins acutely and to sustain their release in normal and hypogonadotropic men.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6767977

Citation

Crowley, W F., et al. "The Biologic Activity of a Potent Analogue of Gonadotropin-releasing Hormone in Normal and Hypogonadotropic Men." The New England Journal of Medicine, vol. 302, no. 19, 1980, pp. 1052-7.
Crowley WF, Beitins IZ, Vale W, et al. The biologic activity of a potent analogue of gonadotropin-releasing hormone in normal and hypogonadotropic men. N Engl J Med. 1980;302(19):1052-7.
Crowley, W. F., Beitins, I. Z., Vale, W., Kliman, B., Rivier, J., Rivier, C., & McArthur, J. W. (1980). The biologic activity of a potent analogue of gonadotropin-releasing hormone in normal and hypogonadotropic men. The New England Journal of Medicine, 302(19), 1052-7.
Crowley WF, et al. The Biologic Activity of a Potent Analogue of Gonadotropin-releasing Hormone in Normal and Hypogonadotropic Men. N Engl J Med. 1980 May 8;302(19):1052-7. PubMed PMID: 6767977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The biologic activity of a potent analogue of gonadotropin-releasing hormone in normal and hypogonadotropic men. AU - Crowley,W F,Jr AU - Beitins,I Z, AU - Vale,W, AU - Kliman,B, AU - Rivier,J, AU - Rivier,C, AU - McArthur,J W, PY - 1980/5/8/pubmed PY - 2001/3/28/medline PY - 1980/5/8/entrez SP - 1052 EP - 7 JF - The New England journal of medicine JO - N Engl J Med VL - 302 IS - 19 N2 - We studied the biologic activity of a long-acting analogue of luteinizing hormone-releasing hormone, D-Trp6-Pro9-NEt-LHRH (LHRHa), in five normal men and four hypogonadotropic men previously unresponsive to natural LHRH. All subjects responded to LHRAa, but there were quantitative and qualitative differences between the normal and hypogonadotropic men. Normal men showed a linear dose-response relation, endogenous gonadal steroid secretion, and an adult pattern of gonadotropin secretion characterized by a high ratio of luteinizing hormone (LH) to follicle-stimulating hormone (FSH). Hypogonadotropic men had improving pituitary responses to each dose of LHRHa (priming response), no demonstrable gonadal steroid secretion, and a prepubertal pattern of gonadotropin release characterized by reversal of the normal ratio of LH to FSH. When compared with native LHRH, LHRHa had an augmented ability to discharge gonadotropins acutely and to sustain their release in normal and hypogonadotropic men. SN - 0028-4793 UR - https://www.unboundmedicine.com/medline/citation/6767977/The_biologic_activity_of_a_potent_analogue_of_gonadotropin_releasing_hormone_in_normal_and_hypogonadotropic_men_ L2 - https://www.nejm.org/doi/10.1056/NEJM198005083021903?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -