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The mechanism of action of a new low-dosed combined oral contraceptive.
Arch Gynecol. 1980; 229(2):107-14.AG

Abstract

The effect of a new low-dosed combined oral contraceptive (OC) containing 37.5 microgram ethinyl estradiol and 0.75 mg lynestrenol (Ovoresta M) upon gonadotropin release and follicular activity was studied in two groups of normally cyclic women. When the administration of the OC was started on day 1 of the cycle, the normal pattern of gonadotropin secretion was disrupted, and the midcycle LH and FSH peak was abolished. The mean level of LH and FSH was somewhat lower than in normal cycles, but the difference was not significant. In one case, serum estradiol rose to the level of the normal cycle indicating follicular activity. Even though there was a rise in serum estradiol to normal values when the OC was started on day 10 of the cycle (in 4/5), both the midcycle LH and FSH surge and ovulation were suppressed (in 3/4). The pituitary response to 100 microgram LH-RH on day 21 was impaired. The LH-response correlated significantly with the serum estradiol concentration. In summary, the low-dosed OC exerts its effect by interfering with follicular ripening and inhibiting the preovulatory LH surge.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

6768343

Citation

Dericks-Tan, J S., et al. "The Mechanism of Action of a New Low-dosed Combined Oral Contraceptive." Archives of Gynecology, vol. 229, no. 2, 1980, pp. 107-14.
Dericks-Tan JS, Schneider K, Taubert HD. The mechanism of action of a new low-dosed combined oral contraceptive. Arch Gynecol. 1980;229(2):107-14.
Dericks-Tan, J. S., Schneider, K., & Taubert, H. D. (1980). The mechanism of action of a new low-dosed combined oral contraceptive. Archives of Gynecology, 229(2), 107-14.
Dericks-Tan JS, Schneider K, Taubert HD. The Mechanism of Action of a New Low-dosed Combined Oral Contraceptive. Arch Gynecol. 1980;229(2):107-14. PubMed PMID: 6768343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The mechanism of action of a new low-dosed combined oral contraceptive. AU - Dericks-Tan,J S, AU - Schneider,K, AU - Taubert,H D, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez KW - Biology KW - Clinical Research KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Contraceptive Mode Of Action KW - Endocrine System KW - Estradiol KW - Estrogens KW - Ethinyl Estradiol KW - Family Planning KW - Follicle Stimulating Hormone KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Luteinizing Hormone KW - Lynestrenol KW - Oral Contraceptives KW - Oral Contraceptives, Combined KW - Oral Contraceptives, Low-dose KW - Ovulation Suppression KW - Physiology KW - Pituitary Hormone Releasing Hormones KW - Research Methodology SP - 107 EP - 14 JF - Archives of gynecology JO - Arch Gynecol VL - 229 IS - 2 N2 - The effect of a new low-dosed combined oral contraceptive (OC) containing 37.5 microgram ethinyl estradiol and 0.75 mg lynestrenol (Ovoresta M) upon gonadotropin release and follicular activity was studied in two groups of normally cyclic women. When the administration of the OC was started on day 1 of the cycle, the normal pattern of gonadotropin secretion was disrupted, and the midcycle LH and FSH peak was abolished. The mean level of LH and FSH was somewhat lower than in normal cycles, but the difference was not significant. In one case, serum estradiol rose to the level of the normal cycle indicating follicular activity. Even though there was a rise in serum estradiol to normal values when the OC was started on day 10 of the cycle (in 4/5), both the midcycle LH and FSH surge and ovulation were suppressed (in 3/4). The pituitary response to 100 microgram LH-RH on day 21 was impaired. The LH-response correlated significantly with the serum estradiol concentration. In summary, the low-dosed OC exerts its effect by interfering with follicular ripening and inhibiting the preovulatory LH surge. SN - 0170-9925 UR - https://www.unboundmedicine.com/medline/citation/6768343/The_mechanism_of_action_of_a_new_low_dosed_combined_oral_contraceptive_ DB - PRIME DP - Unbound Medicine ER -