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Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy.
Horm Metab Res Suppl 1980; 9:105-7HM

Abstract

The therapeutic efficacy of thioctic acid was studied in patients with peripheral diabetic neuropathy. In a double-blind study ten diabetics were treated with thioctic acid or a placebo for 21 days. In a second study ten diabetics were also treated with thioctic acid intravenously (i.v.) for 21 days. Before and on the 11th and 21st day of treatment, we examined the clinical neurological state, the vibration sense according to biothesiometry, the nerve conduction velocity, and the degree of diabetic control. In addition the patients were asked about neuropathic complaints. The therapeutic efficacy of oral or i.v. thioctic acid could not be verified by measurements of the nerve conduction velocity or the vibration sensibility. No effect of oral thioctic acid on subjective complaints was observed. However, i.v. treatment with thioctic acid resulted in a distinct improvement of subjective complaints.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

6769773

Citation

Sachse, G, and B Willms. "Efficacy of Thioctic Acid in the Therapy of Peripheral Diabetic Neuropathy." Hormone and Metabolic Research. Supplement Series, vol. 9, 1980, pp. 105-7.
Sachse G, Willms B. Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy. Horm Metab Res Suppl. 1980;9:105-7.
Sachse, G., & Willms, B. (1980). Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy. Hormone and Metabolic Research. Supplement Series, 9, pp. 105-7.
Sachse G, Willms B. Efficacy of Thioctic Acid in the Therapy of Peripheral Diabetic Neuropathy. Horm Metab Res Suppl. 1980;9:105-7. PubMed PMID: 6769773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy. AU - Sachse,G, AU - Willms,B, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 105 EP - 7 JF - Hormone and metabolic research. Supplement series JO - Horm. Metab. Res. Suppl. VL - 9 N2 - The therapeutic efficacy of thioctic acid was studied in patients with peripheral diabetic neuropathy. In a double-blind study ten diabetics were treated with thioctic acid or a placebo for 21 days. In a second study ten diabetics were also treated with thioctic acid intravenously (i.v.) for 21 days. Before and on the 11th and 21st day of treatment, we examined the clinical neurological state, the vibration sense according to biothesiometry, the nerve conduction velocity, and the degree of diabetic control. In addition the patients were asked about neuropathic complaints. The therapeutic efficacy of oral or i.v. thioctic acid could not be verified by measurements of the nerve conduction velocity or the vibration sensibility. No effect of oral thioctic acid on subjective complaints was observed. However, i.v. treatment with thioctic acid resulted in a distinct improvement of subjective complaints. SN - 0170-5903 UR - https://www.unboundmedicine.com/medline/citation/6769773/Efficacy_of_thioctic_acid_in_the_therapy_of_peripheral_diabetic_neuropathy_ L2 - https://medlineplus.gov/diabeticnerveproblems.html DB - PRIME DP - Unbound Medicine ER -