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MDA and DOM: substituted amphetamines that do not produce amphetamine-like discriminative stimuli in the rat.
Psychopharmacology (Berl). 1980; 67(3):311-2.P

Abstract

3,4-Methylenedioxyamphetamine (MDA) and 2,5-dimethoxy-4-methylamphetamine (DOM) are amphetamine congeners that produce both amphetamine-like and LSD-like effects. To evaluate whether MDA and DOM should be classed with amphetamine, their capacity to produce amphetamine-like discriminative stimuli was assessed. Rats were trained to discriminate between saline and 1.0 mg/kg d-amphetamine in a two choice, discrete trial shock avoidance paradigm. Neither MDA nor DOM produced any amphetamine-appropriate responding when tested over a 30-fold dose range. The specificity of the procedure to detect amphetamine-like effects was demonstrated by the failure of LSD to produce any amphetamine-appropriate responding. These results suggest that neither MDA nor DOM should be classed as amphetamine-like agents.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6770411

Citation

Shannon, H E.. "MDA and DOM: Substituted Amphetamines That Do Not Produce Amphetamine-like Discriminative Stimuli in the Rat." Psychopharmacology, vol. 67, no. 3, 1980, pp. 311-2.
Shannon HE. MDA and DOM: substituted amphetamines that do not produce amphetamine-like discriminative stimuli in the rat. Psychopharmacology (Berl). 1980;67(3):311-2.
Shannon, H. E. (1980). MDA and DOM: substituted amphetamines that do not produce amphetamine-like discriminative stimuli in the rat. Psychopharmacology, 67(3), 311-2.
Shannon HE. MDA and DOM: Substituted Amphetamines That Do Not Produce Amphetamine-like Discriminative Stimuli in the Rat. Psychopharmacology (Berl). 1980;67(3):311-2. PubMed PMID: 6770411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MDA and DOM: substituted amphetamines that do not produce amphetamine-like discriminative stimuli in the rat. A1 - Shannon,H E, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez SP - 311 EP - 2 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 67 IS - 3 N2 - 3,4-Methylenedioxyamphetamine (MDA) and 2,5-dimethoxy-4-methylamphetamine (DOM) are amphetamine congeners that produce both amphetamine-like and LSD-like effects. To evaluate whether MDA and DOM should be classed with amphetamine, their capacity to produce amphetamine-like discriminative stimuli was assessed. Rats were trained to discriminate between saline and 1.0 mg/kg d-amphetamine in a two choice, discrete trial shock avoidance paradigm. Neither MDA nor DOM produced any amphetamine-appropriate responding when tested over a 30-fold dose range. The specificity of the procedure to detect amphetamine-like effects was demonstrated by the failure of LSD to produce any amphetamine-appropriate responding. These results suggest that neither MDA nor DOM should be classed as amphetamine-like agents. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/6770411/MDA_and_DOM:_substituted_amphetamines_that_do_not_produce_amphetamine_like_discriminative_stimuli_in_the_rat_ DB - PRIME DP - Unbound Medicine ER -