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The effect of iopanoic acid on the regulation of thyrotropin secretion in euthyroid subjects.
J Clin Endocrinol Metab. 1980 Aug; 51(2):399-403.JC

Abstract

Oral cholecystographic agents induce a decrease in serum T3 and an increase in serum T4 and rT3 concentrations in normal subjects. However, their effect on TSH secretion in man is unclear. In the present study, the serum TSH concentration was increased above baseline values 5 days after the administration of 3 g iopanoic acid (IA) in five of six euthyroid volunteers (an increase of borderline significance), and the TSH response to TRH was significantly augmented after IA administration. In four other euthyroid subjects who had received IA 3 days earlier, the administration of T3 (5 microgram, five times daily) for the next 2 days restored the serum T3 concentration toward baseline values and prevented the IA-induced increase in TRH-stimulated serum TSH concentrations. It is concluded from the present study that IA enhances pituitary thyrotroph sensitivity to TRH and that this effect may be related, at least in part, to the IA-induced decrease in circulating T3 as well as the previously demonstrated inhibitory effect of IA on the pituitary conversion of T4 to T3. This decrease in the serum T3 concentration after IA administration is due primarily to inhibition of peripheral 5-monodeiodination of T4 and, possibly, to a direct inhibitoy effect of excess iodide on the release of T3 from the thyroid.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

6772664

Citation

Kleinmann, R E., et al. "The Effect of Iopanoic Acid On the Regulation of Thyrotropin Secretion in Euthyroid Subjects." The Journal of Clinical Endocrinology and Metabolism, vol. 51, no. 2, 1980, pp. 399-403.
Kleinmann RE, Vagenakis AG, Braverman LE. The effect of iopanoic acid on the regulation of thyrotropin secretion in euthyroid subjects. J Clin Endocrinol Metab. 1980;51(2):399-403.
Kleinmann, R. E., Vagenakis, A. G., & Braverman, L. E. (1980). The effect of iopanoic acid on the regulation of thyrotropin secretion in euthyroid subjects. The Journal of Clinical Endocrinology and Metabolism, 51(2), 399-403.
Kleinmann RE, Vagenakis AG, Braverman LE. The Effect of Iopanoic Acid On the Regulation of Thyrotropin Secretion in Euthyroid Subjects. J Clin Endocrinol Metab. 1980;51(2):399-403. PubMed PMID: 6772664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of iopanoic acid on the regulation of thyrotropin secretion in euthyroid subjects. AU - Kleinmann,R E, AU - Vagenakis,A G, AU - Braverman,L E, PY - 1980/8/1/pubmed PY - 1980/8/1/medline PY - 1980/8/1/entrez SP - 399 EP - 403 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 51 IS - 2 N2 - Oral cholecystographic agents induce a decrease in serum T3 and an increase in serum T4 and rT3 concentrations in normal subjects. However, their effect on TSH secretion in man is unclear. In the present study, the serum TSH concentration was increased above baseline values 5 days after the administration of 3 g iopanoic acid (IA) in five of six euthyroid volunteers (an increase of borderline significance), and the TSH response to TRH was significantly augmented after IA administration. In four other euthyroid subjects who had received IA 3 days earlier, the administration of T3 (5 microgram, five times daily) for the next 2 days restored the serum T3 concentration toward baseline values and prevented the IA-induced increase in TRH-stimulated serum TSH concentrations. It is concluded from the present study that IA enhances pituitary thyrotroph sensitivity to TRH and that this effect may be related, at least in part, to the IA-induced decrease in circulating T3 as well as the previously demonstrated inhibitory effect of IA on the pituitary conversion of T4 to T3. This decrease in the serum T3 concentration after IA administration is due primarily to inhibition of peripheral 5-monodeiodination of T4 and, possibly, to a direct inhibitoy effect of excess iodide on the release of T3 from the thyroid. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/6772664/The_effect_of_iopanoic_acid_on_the_regulation_of_thyrotropin_secretion_in_euthyroid_subjects_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-51-2-399 DB - PRIME DP - Unbound Medicine ER -