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Hyperprolactinemia in cases of infertility and amenorrhea.
Acta Obstet Gynecol Scand. 1980; 59(2):137-41.AO

Abstract

Of 17 patients with longstanding (3--15 years, mean 7.7 years) amenorrhea and hyperprolactinemia, 8 developed their amenorrhea after the use of oral contraceptives (Group I) and 9 became amenorrhoic spontaneously (Group II). There were no differences between the groups with respect to the basal serum levels of FSH, LH, low polar estrogens (estradiol-17 beta + estrone) and prolactin. Tomography revealed pituitary adenoma in four patients. One of these developed symptoms of her tumor during pregnancy; the symptoms disappeared after delivery. The other patients with tumors are checked twice a year and have not yet received any treatment. The patients with no detectable tumors were treated with bromocriptine starting with 1.25 X 3 daily. The peripheral serum levels of prolactin, FSH, LH, low polar estrogens and progesterone were determined once a week and if the prolactin levels remained high, the bromocriptine dose was increased. All these patients started to menstruate as soon as prolactin returned to normal levels (below 25 micrograms/l). All patients who wished to became pregnant, i.e. 6 patients. Three were delivered by cesarean section, one had a normal delivery and two are still pregnant. There was no difference between Group I and Group II in the dose required or in the duration of treatment before menstruation started. Three cases of galactorrhea were found.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6773290

Citation

Furuhjelm, M, et al. "Hyperprolactinemia in Cases of Infertility and Amenorrhea." Acta Obstetricia Et Gynecologica Scandinavica, vol. 59, no. 2, 1980, pp. 137-41.
Furuhjelm M, Rydner T, Carlström K. Hyperprolactinemia in cases of infertility and amenorrhea. Acta Obstet Gynecol Scand. 1980;59(2):137-41.
Furuhjelm, M., Rydner, T., & Carlström, K. (1980). Hyperprolactinemia in cases of infertility and amenorrhea. Acta Obstetricia Et Gynecologica Scandinavica, 59(2), 137-41.
Furuhjelm M, Rydner T, Carlström K. Hyperprolactinemia in Cases of Infertility and Amenorrhea. Acta Obstet Gynecol Scand. 1980;59(2):137-41. PubMed PMID: 6773290.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperprolactinemia in cases of infertility and amenorrhea. AU - Furuhjelm,M, AU - Rydner,T, AU - Carlström,K, PY - 1980/1/1/pubmed PY - 1980/1/1/medline PY - 1980/1/1/entrez KW - Amenorrhea--etiology KW - Biology KW - Clinical Research KW - Diseases KW - Endocrine System KW - Estradiol--analysis KW - Estrogens KW - Estrone--analysis KW - Follicle Stimulating Hormone--analysis KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Luteinizing Hormone--analysis KW - Menstruation Disorders KW - Physiology KW - Pituitary Hormones KW - Progestational Hormones KW - Progesterone--analysis KW - Prolactin--analysis KW - Research Methodology SP - 137 EP - 41 JF - Acta obstetricia et gynecologica Scandinavica JO - Acta Obstet Gynecol Scand VL - 59 IS - 2 N2 - Of 17 patients with longstanding (3--15 years, mean 7.7 years) amenorrhea and hyperprolactinemia, 8 developed their amenorrhea after the use of oral contraceptives (Group I) and 9 became amenorrhoic spontaneously (Group II). There were no differences between the groups with respect to the basal serum levels of FSH, LH, low polar estrogens (estradiol-17 beta + estrone) and prolactin. Tomography revealed pituitary adenoma in four patients. One of these developed symptoms of her tumor during pregnancy; the symptoms disappeared after delivery. The other patients with tumors are checked twice a year and have not yet received any treatment. The patients with no detectable tumors were treated with bromocriptine starting with 1.25 X 3 daily. The peripheral serum levels of prolactin, FSH, LH, low polar estrogens and progesterone were determined once a week and if the prolactin levels remained high, the bromocriptine dose was increased. All these patients started to menstruate as soon as prolactin returned to normal levels (below 25 micrograms/l). All patients who wished to became pregnant, i.e. 6 patients. Three were delivered by cesarean section, one had a normal delivery and two are still pregnant. There was no difference between Group I and Group II in the dose required or in the duration of treatment before menstruation started. Three cases of galactorrhea were found. SN - 0001-6349 UR - https://www.unboundmedicine.com/medline/citation/6773290/Hyperprolactinemia_in_cases_of_infertility_and_amenorrhea_ DB - PRIME DP - Unbound Medicine ER -