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Congenital central hypoventilation and sleep state.
Pediatrics. 1980 Sep; 66(3):425-8.Ped

Abstract

Congenital central hypoventilation (Ondine's curse) is described in an infant with persistant symptoms throughout the first nine months of life. Respiratory control was most severely affected in quiet sleep, although abnormalities were present in rapid eye movement (REM) sleep and while awake. Failure of metabolic control in quiet sleep led to profound hypoventilation. Behavioral or "behavioral-like" inputs in the awake state and REM sleep increased ventilation, but not to expected normal levels. The ventilatory response to inhaled 4% CO2 was markedly depressed in all states.

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Publisher Full Text

Authors

Fleming PJ
No affiliation info available
Cade D
No affiliation info available
Bryan MH
No affiliation info available
Bryan AC
No affiliation info available

MeSH

Carbon DioxideFemaleHumansHypoventilationInfant, NewbornRespirationSleep Apnea SyndromesSleep, REMWakefulness

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

6775277

Citation

Fleming, P J., et al. "Congenital Central Hypoventilation and Sleep State." Pediatrics, vol. 66, no. 3, 1980, pp. 425-8.
Fleming PJ, Cade D, Bryan MH, et al. Congenital central hypoventilation and sleep state. Pediatrics. 1980;66(3):425-8.
Fleming, P. J., Cade, D., Bryan, M. H., & Bryan, A. C. (1980). Congenital central hypoventilation and sleep state. Pediatrics, 66(3), 425-8.
Fleming PJ, et al. Congenital Central Hypoventilation and Sleep State. Pediatrics. 1980;66(3):425-8. PubMed PMID: 6775277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Congenital central hypoventilation and sleep state. AU - Fleming,P J, AU - Cade,D, AU - Bryan,M H, AU - Bryan,A C, PY - 1980/9/1/pubmed PY - 1980/9/1/medline PY - 1980/9/1/entrez SP - 425 EP - 8 JF - Pediatrics JO - Pediatrics VL - 66 IS - 3 N2 - Congenital central hypoventilation (Ondine's curse) is described in an infant with persistant symptoms throughout the first nine months of life. Respiratory control was most severely affected in quiet sleep, although abnormalities were present in rapid eye movement (REM) sleep and while awake. Failure of metabolic control in quiet sleep led to profound hypoventilation. Behavioral or "behavioral-like" inputs in the awake state and REM sleep increased ventilation, but not to expected normal levels. The ventilatory response to inhaled 4% CO2 was markedly depressed in all states. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/6775277/Congenital_central_hypoventilation_and_sleep_state_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=6775277 DB - PRIME DP - Unbound Medicine ER -