[The effect of the herbicide Dinoseb-acetate (Aretit) on transaminase (GOT, GPT) activity in the blood serum and muscles of the Japanese quail (Coturnix coturnix japonica)].Vet Med (Praha). 1980 Nov; 25(11):697-702.VM
An experiment was undertaken to study the effect of the dinoseb-acetate (Aretit) herbicide, administered in drinking water at a concentration of 100 and 200 mg x 1(-1) for four days, on the activity of transaminases (GOT and GPT) in the blood serum and muscle of the Japanese quail (Coturnix coturnix japonica). GOT had higher activity values in the blood serum and muscle of the control and test birds, as compared with GPT. The herbicide increases GOT activity in the blood serum, whereas the GPT value remains unchanged. In muscle, the activity of GOT decreases as a result of the action of dinoseb-acetate and GPT activity remains unchanged. Under in vitro conditions, dinoseb-acetate (concentrated 0.01 to 1000 mg x 1(-1)) increases GOT activity in the blood serum and muscle, GPT activity remaining the same. It is assumed that transaminases are specifically involved in the adaptation mechanisms of the animals to dinoseb-acetate intoxication.