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Incidence and severity of viral hepatitis in pregnancy.

Abstract

A prospective field study was carried out during an epidemic of non-A non-B hepatitis for determining the incidence and severity of hepatitis in pregnant women, nonpregnant women of child bearing age and men (15 to 45 years old). In 36 (17.3 percent) of 208 pregnant women viral hepatitis developed, as compared to 71 (2.1 percent) of 3,350 nonpregnant women and 107 (2.8 percent) of 3,822 men. The incidence of disease in pregnant women was higher than in the two control groups. The incidence of viral hepatitis in the first, second and third trimesters was 8.8 percent, 19.4 percent, and 18.6 percent, respectively. The incidence in all three trimesters was higher, when compared to that in nonpregnant women. In eight pregnant women (22.2 percent) with viral hepatitis, fulminant hepatic failure developed, as compared to its occurrence in three men (2.8 percent) and in no nonpregnant women. This significantly increased incidence of fulminant hepatitis in pregnancy was indicative of a greater severity of hepatitis during pregnancy. Increased susceptibility to fulminant hepatitis was observed exclusively in the last trimester. Nonfulminant viral hepatitis did not influence the course of pregnancy or fetal well-being. Fetal loss in fatal fulminant hepatitis was a consequence of maternal death and could not be ascribed to direct effect on the fetus or pregnancy.

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  • Publisher Full Text
  • Authors

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    Source

    The American journal of medicine 70:2 1981 Feb pg 252-5

    MeSH

    Adolescent
    Adult
    Disease Outbreaks
    Female
    Fetal Death
    Hepatitis C
    Hepatitis, Viral, Human
    Humans
    India
    Middle Aged
    Pregnancy
    Pregnancy Complications, Infectious

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    6781338

    Citation

    Khuroo, M S., et al. "Incidence and Severity of Viral Hepatitis in Pregnancy." The American Journal of Medicine, vol. 70, no. 2, 1981, pp. 252-5.
    Khuroo MS, Teli MR, Skidmore S, et al. Incidence and severity of viral hepatitis in pregnancy. Am J Med. 1981;70(2):252-5.
    Khuroo, M. S., Teli, M. R., Skidmore, S., Sofi, M. A., & Khuroo, M. I. (1981). Incidence and severity of viral hepatitis in pregnancy. The American Journal of Medicine, 70(2), pp. 252-5.
    Khuroo MS, et al. Incidence and Severity of Viral Hepatitis in Pregnancy. Am J Med. 1981;70(2):252-5. PubMed PMID: 6781338.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Incidence and severity of viral hepatitis in pregnancy. AU - Khuroo,M S, AU - Teli,M R, AU - Skidmore,S, AU - Sofi,M A, AU - Khuroo,M I, PY - 1981/2/1/pubmed PY - 1981/2/1/medline PY - 1981/2/1/entrez KW - Asia KW - Biology KW - Data Collection KW - Developing Countries KW - Diseases KW - Health KW - Hepatic Effects KW - Incidence KW - India KW - Maternal Nutrition KW - Measurement KW - Nutrition KW - Physiology KW - Pregnancy KW - Pregnancy Outcomes KW - Prospective Studies KW - Reproduction KW - Research Methodology KW - Southern Asia KW - Studies KW - Viral Diseases SP - 252 EP - 5 JF - The American journal of medicine JO - Am. J. Med. VL - 70 IS - 2 N2 - A prospective field study was carried out during an epidemic of non-A non-B hepatitis for determining the incidence and severity of hepatitis in pregnant women, nonpregnant women of child bearing age and men (15 to 45 years old). In 36 (17.3 percent) of 208 pregnant women viral hepatitis developed, as compared to 71 (2.1 percent) of 3,350 nonpregnant women and 107 (2.8 percent) of 3,822 men. The incidence of disease in pregnant women was higher than in the two control groups. The incidence of viral hepatitis in the first, second and third trimesters was 8.8 percent, 19.4 percent, and 18.6 percent, respectively. The incidence in all three trimesters was higher, when compared to that in nonpregnant women. In eight pregnant women (22.2 percent) with viral hepatitis, fulminant hepatic failure developed, as compared to its occurrence in three men (2.8 percent) and in no nonpregnant women. This significantly increased incidence of fulminant hepatitis in pregnancy was indicative of a greater severity of hepatitis during pregnancy. Increased susceptibility to fulminant hepatitis was observed exclusively in the last trimester. Nonfulminant viral hepatitis did not influence the course of pregnancy or fetal well-being. Fetal loss in fatal fulminant hepatitis was a consequence of maternal death and could not be ascribed to direct effect on the fetus or pregnancy. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/6781338/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9343(81)90758-0 DB - PRIME DP - Unbound Medicine ER -