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Blood-oxygen affinity and sickling in sickle cell disease: effect of prior deoxygenation.
J Lab Clin Med. 1981 Oct; 98(4):492-9.JL

Abstract

The influence of prior deoxygenation on whole blood-oxygen affinity was determined in samples from persons with sickle cell anemia (SS blood) and compared to blood from normal and anemic subjects (AA blood). The oxygen affinity of SS blood (measured as P50) is significantly decreased when this blood is exposed for 30 min to nitrogen before the determination of the oxygen equilibrium curve. The decrease is directly related to the number of sickle cells that are present in the samples. The present work emphasizes the importance of experimental conditions on the results of the determination of SS blood-oxygen affinity and the difficulties inherent in the evaluation of in vivo oxygen transport in sickle cell disease.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

6793678

Citation

Sinet, M, and J J. Pocidalo. "Blood-oxygen Affinity and Sickling in Sickle Cell Disease: Effect of Prior Deoxygenation." The Journal of Laboratory and Clinical Medicine, vol. 98, no. 4, 1981, pp. 492-9.
Sinet M, Pocidalo JJ. Blood-oxygen affinity and sickling in sickle cell disease: effect of prior deoxygenation. J Lab Clin Med. 1981;98(4):492-9.
Sinet, M., & Pocidalo, J. J. (1981). Blood-oxygen affinity and sickling in sickle cell disease: effect of prior deoxygenation. The Journal of Laboratory and Clinical Medicine, 98(4), 492-9.
Sinet M, Pocidalo JJ. Blood-oxygen Affinity and Sickling in Sickle Cell Disease: Effect of Prior Deoxygenation. J Lab Clin Med. 1981;98(4):492-9. PubMed PMID: 6793678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood-oxygen affinity and sickling in sickle cell disease: effect of prior deoxygenation. AU - Sinet,M, AU - Pocidalo,J J, PY - 1981/10/1/pubmed PY - 1981/10/1/medline PY - 1981/10/1/entrez SP - 492 EP - 9 JF - The Journal of laboratory and clinical medicine JO - J Lab Clin Med VL - 98 IS - 4 N2 - The influence of prior deoxygenation on whole blood-oxygen affinity was determined in samples from persons with sickle cell anemia (SS blood) and compared to blood from normal and anemic subjects (AA blood). The oxygen affinity of SS blood (measured as P50) is significantly decreased when this blood is exposed for 30 min to nitrogen before the determination of the oxygen equilibrium curve. The decrease is directly related to the number of sickle cells that are present in the samples. The present work emphasizes the importance of experimental conditions on the results of the determination of SS blood-oxygen affinity and the difficulties inherent in the evaluation of in vivo oxygen transport in sickle cell disease. SN - 0022-2143 UR - https://www.unboundmedicine.com/medline/citation/6793678/Blood_oxygen_affinity_and_sickling_in_sickle_cell_disease:_effect_of_prior_deoxygenation_ L2 - http://www.diseaseinfosearch.org/result/6589 DB - PRIME DP - Unbound Medicine ER -