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[Thyroid hormones and thyroid reserve in preclinical hypothyroidism].
Schweiz Med Wochenschr. 1981 Dec 05; 111(49):1904-5.SM

Abstract

Preclinical hypothyroidism (i.e. basal thyroxine within the normal laboratory range, basal TSH normal or elevated and exaggerated TSH response to TRH) is a biochemical constellation of uncertain clinical relevance. The oral TRH test with simultaneous measurements of TSH and thyroid hormones before and 3 h after 40 mg TRH provides information about both pituitary and thyroid reserve. In a group of female patients with preclinical hypothyroidism, basal thyroxine but not triiodothyronine was found to be clearly diminished compared with a group of healthy female controls, indicating a slight thyroid hormone deficiency. Furthermore, a progressively reduced thyroid reserve of T4 and especially of T3 was seen to be closely related to elevation of basal TSH as an expression of thyroid cell insufficiency. These data emphasize the clinical importance of TSH elevation despite normal thyroxine levels as a better individual sign of impending primary hypothyroidism.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ger

PubMed ID

6800029

Citation

Noelpp, B, et al. "[Thyroid Hormones and Thyroid Reserve in Preclinical Hypothyroidism]." Schweizerische Medizinische Wochenschrift, vol. 111, no. 49, 1981, pp. 1904-5.
Noelpp B, Staub JJ, Heinimann T, et al. [Thyroid hormones and thyroid reserve in preclinical hypothyroidism]. Schweiz Med Wochenschr. 1981;111(49):1904-5.
Noelpp, B., Staub, J. J., Heinimann, T., Gräni, R., & Girard, J. (1981). [Thyroid hormones and thyroid reserve in preclinical hypothyroidism]. Schweizerische Medizinische Wochenschrift, 111(49), 1904-5.
Noelpp B, et al. [Thyroid Hormones and Thyroid Reserve in Preclinical Hypothyroidism]. Schweiz Med Wochenschr. 1981 Dec 5;111(49):1904-5. PubMed PMID: 6800029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Thyroid hormones and thyroid reserve in preclinical hypothyroidism]. AU - Noelpp,B, AU - Staub,J J, AU - Heinimann,T, AU - Gräni,R, AU - Girard,J, PY - 1981/12/5/pubmed PY - 1981/12/5/medline PY - 1981/12/5/entrez SP - 1904 EP - 5 JF - Schweizerische medizinische Wochenschrift JO - Schweiz Med Wochenschr VL - 111 IS - 49 N2 - Preclinical hypothyroidism (i.e. basal thyroxine within the normal laboratory range, basal TSH normal or elevated and exaggerated TSH response to TRH) is a biochemical constellation of uncertain clinical relevance. The oral TRH test with simultaneous measurements of TSH and thyroid hormones before and 3 h after 40 mg TRH provides information about both pituitary and thyroid reserve. In a group of female patients with preclinical hypothyroidism, basal thyroxine but not triiodothyronine was found to be clearly diminished compared with a group of healthy female controls, indicating a slight thyroid hormone deficiency. Furthermore, a progressively reduced thyroid reserve of T4 and especially of T3 was seen to be closely related to elevation of basal TSH as an expression of thyroid cell insufficiency. These data emphasize the clinical importance of TSH elevation despite normal thyroxine levels as a better individual sign of impending primary hypothyroidism. SN - 0036-7672 UR - https://www.unboundmedicine.com/medline/citation/6800029/[Thyroid_hormones_and_thyroid_reserve_in_preclinical_hypothyroidism]_ L2 - https://medlineplus.gov/hypothyroidism.html DB - PRIME DP - Unbound Medicine ER -