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Prolactin response to metoclopramide in hyperthyroidism.
J Clin Endocrinol Metab. 1982 Jul; 55(1):175-7.JC

Abstract

The response of PRL to the oral administration of the dopamine receptor-blocking agent metoclopramide and the effect of metoclopramide on the TRH-induced release of PRL and TSH were measured in eight patients with hyperthyroidism and in eight age- and sex-matched euthyroid controls. As expected from the known direct inhibitory influence of thyroid hormones on pituitary TSH secretion, there was no TSH rise in response to metoclopramide in either group. PRL levels, on the other hand, rose significantly after the administration of metoclopramide in both the hyperthyroid and euthyroid subjects (P less than 0.0005 at 60 and 120 min). However, the increase in PRL at 120 min was significantly less in the hyperthyroid subjects than in the euthyroid controls (P less than 0.0025). Furthermore, the administration of metoclopramide failed to reestablish normal responsiveness of either PRL or TSH to TRH in the hyperthyroid subjects. We have previously suggested that thyroid hormones inhibit PRL secretion by stimulating the hypothalamic secretion of dopamine. These results suggest, however, that elevated levels of thyroid hormones also inhibit PRL release directly at the anterior pituitary level.

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Authors

Sawers JS
No affiliation info available
Kellett HA
No affiliation info available
Brown NS
No affiliation info available
Seth J
No affiliation info available
Toft AD
No affiliation info available

MeSH

Administration, OralFemaleGraves DiseaseHumansHyperthyroidismMaleMetoclopramideProlactinThyrotropinThyrotropin-Releasing HormoneTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

6804483

Citation

Sawers, J S., et al. "Prolactin Response to Metoclopramide in Hyperthyroidism." The Journal of Clinical Endocrinology and Metabolism, vol. 55, no. 1, 1982, pp. 175-7.
Sawers JS, Kellett HA, Brown NS, et al. Prolactin response to metoclopramide in hyperthyroidism. J Clin Endocrinol Metab. 1982;55(1):175-7.
Sawers, J. S., Kellett, H. A., Brown, N. S., Seth, J., & Toft, A. D. (1982). Prolactin response to metoclopramide in hyperthyroidism. The Journal of Clinical Endocrinology and Metabolism, 55(1), 175-7.
Sawers JS, et al. Prolactin Response to Metoclopramide in Hyperthyroidism. J Clin Endocrinol Metab. 1982;55(1):175-7. PubMed PMID: 6804483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prolactin response to metoclopramide in hyperthyroidism. AU - Sawers,J S, AU - Kellett,H A, AU - Brown,N S, AU - Seth,J, AU - Toft,A D, PY - 1982/7/1/pubmed PY - 1982/7/1/medline PY - 1982/7/1/entrez SP - 175 EP - 7 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 55 IS - 1 N2 - The response of PRL to the oral administration of the dopamine receptor-blocking agent metoclopramide and the effect of metoclopramide on the TRH-induced release of PRL and TSH were measured in eight patients with hyperthyroidism and in eight age- and sex-matched euthyroid controls. As expected from the known direct inhibitory influence of thyroid hormones on pituitary TSH secretion, there was no TSH rise in response to metoclopramide in either group. PRL levels, on the other hand, rose significantly after the administration of metoclopramide in both the hyperthyroid and euthyroid subjects (P less than 0.0005 at 60 and 120 min). However, the increase in PRL at 120 min was significantly less in the hyperthyroid subjects than in the euthyroid controls (P less than 0.0025). Furthermore, the administration of metoclopramide failed to reestablish normal responsiveness of either PRL or TSH to TRH in the hyperthyroid subjects. We have previously suggested that thyroid hormones inhibit PRL secretion by stimulating the hypothalamic secretion of dopamine. These results suggest, however, that elevated levels of thyroid hormones also inhibit PRL release directly at the anterior pituitary level. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/6804483/Prolactin_response_to_metoclopramide_in_hyperthyroidism_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-55-1-175 DB - PRIME DP - Unbound Medicine ER -