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Evidence for a defective inhibition of pentagastrin-stimulated gastric acid secretion by antral distension in the duodenal ulcer patient.
Gastroenterology. 1978 Sep; 75(3):363-7.G

Abstract

Graded antrum distension by 50-, 100-, and 150-ml balloon volumes significantly stimulated gastric acid secretion in 6 duodenal ulcer patients, but had no stimulatory effect in 6 healthy subjects. Antrum distension by 150-ml balloon volume had no effect on the acid response to submaximal stimulation by a continuous intravenous infusion of pentagastrin in the duodenal ulcer patients, but significantly inhibited this response in the healthy subjects. The inhibition by antrum distension in the healthy subjects amounted to 20%. The results suggest that antrum distension elicits stimulatory as well as inhibitory mechanisms in man with inhibition of acid secretion predominating in healthy subjects and stimulation of acid secretion predominating in duodenal ulcer patients. The mechanism of inhibition is unknown.

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Authors

Schöön IM
No affiliation info available
Bergegårdh S
No affiliation info available
Grötzinger U
No affiliation info available
Olbe L
No affiliation info available

MeSH

AdultDilatationDuodenal UlcerFemaleGastric JuiceHumansMaleMiddle AgedPentagastrinPyloric AntrumStimulation, Chemical

Pub Type(s)

Journal Article

Language

eng

PubMed ID

680489

Citation

Schöön, I M., et al. "Evidence for a Defective Inhibition of Pentagastrin-stimulated Gastric Acid Secretion By Antral Distension in the Duodenal Ulcer Patient." Gastroenterology, vol. 75, no. 3, 1978, pp. 363-7.
Schöön IM, Bergegårdh S, Grötzinger U, et al. Evidence for a defective inhibition of pentagastrin-stimulated gastric acid secretion by antral distension in the duodenal ulcer patient. Gastroenterology. 1978;75(3):363-7.
Schöön, I. M., Bergegårdh, S., Grötzinger, U., & Olbe, L. (1978). Evidence for a defective inhibition of pentagastrin-stimulated gastric acid secretion by antral distension in the duodenal ulcer patient. Gastroenterology, 75(3), 363-7.
Schöön IM, et al. Evidence for a Defective Inhibition of Pentagastrin-stimulated Gastric Acid Secretion By Antral Distension in the Duodenal Ulcer Patient. Gastroenterology. 1978;75(3):363-7. PubMed PMID: 680489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for a defective inhibition of pentagastrin-stimulated gastric acid secretion by antral distension in the duodenal ulcer patient. AU - Schöön,I M, AU - Bergegårdh,S, AU - Grötzinger,U, AU - Olbe,L, PY - 1978/9/1/pubmed PY - 1978/9/1/medline PY - 1978/9/1/entrez SP - 363 EP - 7 JF - Gastroenterology JO - Gastroenterology VL - 75 IS - 3 N2 - Graded antrum distension by 50-, 100-, and 150-ml balloon volumes significantly stimulated gastric acid secretion in 6 duodenal ulcer patients, but had no stimulatory effect in 6 healthy subjects. Antrum distension by 150-ml balloon volume had no effect on the acid response to submaximal stimulation by a continuous intravenous infusion of pentagastrin in the duodenal ulcer patients, but significantly inhibited this response in the healthy subjects. The inhibition by antrum distension in the healthy subjects amounted to 20%. The results suggest that antrum distension elicits stimulatory as well as inhibitory mechanisms in man with inhibition of acid secretion predominating in healthy subjects and stimulation of acid secretion predominating in duodenal ulcer patients. The mechanism of inhibition is unknown. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/680489/Evidence_for_a_defective_inhibition_of_pentagastrin_stimulated_gastric_acid_secretion_by_antral_distension_in_the_duodenal_ulcer_patient_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S001650857800178X DB - PRIME DP - Unbound Medicine ER -